Candidate list of genetic modifiers
Entrez Gene IDs are linked to their corresponding NCBI GenBank entry. Gene symbols are linked to the entry for the gene in the HD Research CrossRoads database. Note that a login is required for the HD Research CrossRoads database.
Reference used are 1. HD Maps Study 2. Gayan J et.al
Entrez Gene ID Symbol Name TV-Score Chromosome Band LOD from HD MAPS LOD Gayan from et al
2550 GABBR1 "gamma-aminobutyric acid (GABA) B receptor, 1" 2.5 6 p22.1 2.29
9972 NUP153 nucleoporin 153kDa 3 6 p22.3 2.29
9475 ROCK2 "Rho-associated, coiled-coil containing protein kinase 2" 4 2 p25.1 4.29
51692 CPSF3 "cleavage and polyadenylation specific factor 3, 73kDa" 3 2 p25.1 4.29
10576 CCT2 "chaperonin containing TCP1, subunit 2 (beta)" 3 12 q15 2.86
57122 NUP107 nucleoporin 107kDa 3 12 q15 2.86
3727 JUND jun D proto-oncogene 3 19 p13.11 1.79
5976 UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 3 19 p13.11 1.79
6142 RPL18A ribosomal protein L18a 3 19 p13.11 1.79
58513 EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 3 19 p13.11 1.79
3718 JAK3 Janus kinase 3 2 19 p13.11 1.79
5296 PIK3R2 "phosphoinositide-3-kinase, regulatory subunit 2 (beta)" 2.5 19 p13.11 1.79
3337 DNAJB1 "DnaJ (Hsp40) homolog, subfamily B, member 1" 3 19 p13.12 1.79
5566 PRKACA "protein kinase, cAMP-dependent, catalytic, alpha" 3 19 p13.12 1.79
10212 DDX39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A 3 19 p13.12 1.79
4218 RAB8A "RAB8A, member RAS oncogene family" 2.5 19 p13.12 1.79
1785 DNM2 dynamin 2 3 19 p13.2 1.79
2057 EPOR erythropoietin receptor 3 19 p13.2 1.79
5141 PDE4A "phosphodiesterase 4A, cAMP-specific" 4 19 p13.2 1.79
5300 PIN1 "peptidylprolyl cis/trans isomerase, NIMA-interacting 1" 3 19 p13.2 1.79
6597 SMARCA4 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4" 3 19 p13.2 1.79
9230 RAB11B "RAB11B, member RAS oncogene family" 3 19 p13.2 1.79
56949 XAB2 XPA binding protein 2 3 19 p13.2 1.79
3643 INSR insulin receptor 2.5 19 p13.2 1.79
4542 MYO1F myosin IF 0 19 p13.2 1.79
5032 P2RY11 "purinergic receptor P2Y, G-protein coupled, 11" 2 19 p13.2 1.79
10053 AP1M2 "adaptor-related protein complex 1, mu 2 subunit" 0 19 p13.2 1.79
57192 MCOLN1 mucolipin 1 2.5 19 p13.2 1.79
100125288 GLP-1 "zinc finger, GATA-like protein 1" 2 19 p13.2 1.79
513 ATP5D "ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit" 3 19 p13.3 1.79
1938 EEF2 eukaryotic translation elongation factor 2 3 19 p13.3 1.79
4902 NRTN neurturin 4 19 p13.3 1.79
6209 RPS15 ribosomal protein S15 3 19 p13.3 1.79
51343 FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 3 19 p13.3 1.79
57455 REXO1 "REX1, RNA exonuclease 1 homolog (S. cerevisiae)" 3 19 p13.3 1.79
58509 C19orf29 chromosome 19 open reading frame 29 3 19 p13.3 1.79
84823 LMNB2 lamin B2 3 19 p13.3 1.79
1613 DAPK3 death-associated protein kinase 3 0 19 p13.3 1.79
5605 MAP2K2 mitogen-activated protein kinase kinase 2 2 19 p13.3 1.79
51548 SIRT6 sirtuin 6 0 19 p13.3 1.79
116444 GRIN3B "glutamate receptor, ionotropic, N-methyl-D-aspartate 3B" 2 19 p13.3 1.79
7341 SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 3 2 q33.1 1.63
9689 BZW1 basic leucine zipper and W2 domains 1 3 2 q33.1 1.63
23451 SF3B1 "splicing factor 3b, subunit 1, 155kDa" 3 2 q33.1 1.63
841 CASP8 "caspase 8, apoptosis-related cysteine peptidase" 2.5 2 q33.1 1.63
1385 CREB1 cAMP responsive element binding protein 1 3.5 2 q33.3 1.63
7855 FZD5 frizzled family receptor 5 3 2 q33.3 1.63
3300 DNAJB2 "DnaJ (Hsp40) homolog, subfamily B, member 2" 3 2 q35 3.39
8941 CDK5R2 "cyclin-dependent kinase 5, regulatory subunit 2 (p39)" 3 2 q35 3.39
10109 ARPC2 "actin related protein 2/3 complex, subunit 2, 34kDa" 3 2 q35 3.39
6286 S100P S100 calcium binding protein P 3 4 p16.1 1.93 1.49
9948 WDR1 WD repeat domain 1 3 4 p16.1 1.93 1.49
1816 DRD5 dopamine receptor D5 2 4 p16.1 1.93 1.49
118 ADD1 adducin 1 (alpha) 3 4 p16.3 1.93 1.49
3064 HTT huntingtin 4 4 p16.3 1.93 1.49
7469 WHSC2 Wolf-Hirschhorn syndrome candidate 2 3 4 p16.3 1.93 1.49
2868 GRK4 G protein-coupled receptor kinase 4 2 4 p16.3 1.93 1.49
10815 CPLX1 complexin 1 2 4 p16.3 1.93 1.49
3308 HSPA4 heat shock 70kDa protein 4 3.5 5 q31.1 2.02
6500 SKP1 S-phase kinase-associated protein 1 3 5 q31.1 2.02
2107 ETF1 eukaryotic translation termination factor 1 3 5 q31.2 2.02
3313 HSPA9 heat shock 70kDa protein 9 (mortalin) 3 5 q31.2 2.02
7322 UBE2D2 ubiquitin-conjugating enzyme E2D 2 3 5 q31.2 2.02
2676 GFRA3 GDNF family receptor alpha 3 2 5 q31.2 2.02
8841 HDAC3 histone deacetylase 3 4 5 q31.3 2.02
10915 TCERG1 transcription elongation regulator 1 3 5 q32 2.02 3.14
133522 PPARGC1B "peroxisome proliferator-activated receptor gamma, coactivator 1 beta" 3 5 q32 2.02 3.14
2444 FRK fyn-related kinase 3 6 q22.1 2.29 2.48
6206 RPS12 ribosomal protein S12 3 6 q23.2 2.28
9439 MED23 mediator complex subunit 23 3 6 q23.2 2.28
9038 TAAR5 trace amine associated receptor 5 2 6 q23.2 2.28
9287 TAAR2 trace amine associated receptor 2 2 6 q23.2 2.28
9288 TAAR3 trace amine associated receptor 3 (gene/pseudogene) 2 6 q23.2 2.28
83551 TAAR8 trace amine associated receptor 8 2 6 q23.2 2.28
134860 TAAR9 trace amine associated receptor 9 (gene/pseudogene) 2 6 q23.2 2.28
134864 TAAR1 trace amine associated receptor 1 2 6 q23.2 2.28
319100 TAAR6 trace amine associated receptor 6 2 6 q23.2 2.28
4217 MAP3K5 mitogen-activated protein kinase kinase kinase 5 4 6 q23.3 2.28
2911 GRM1 "glutamate receptor, metabotropic 1" 3 6 q24.3 2.28