PFAM ID:GO:0006139
Term :nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Entrez Gene IDs are linked to their corresponding NCBI GenBank entry.
Gene symbols are linked to the entry for the gene in the HD Research CrossRoads database.
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Entrez Gene IDApproved SymbolApproved Name
16AARSalanyl-tRNA synthetase
43ACHEacetylcholinesterase
107ADCY1adenylate cyclase 1 (brain)
116ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary)
117ADCYAP1R1adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
135ADORA2Aadenosine A2a receptor
136ADORA2Badenosine A2b receptor
226ALDOAaldolase A_ fructose-bisphosphate
348APOEapolipoprotein E
367ARandrogen receptor
387RHOAras homolog gene family_ member A
467ATF3activating transcription factor 3
476ATP1A1ATPase_ Na+/K+ transporting_ alpha 1 polypeptide
498ATP5A1ATP synthase_ H+ transporting_ mitochondrial F1 complex_ alpha subunit 1_ cardiac muscle
506ATP5BATP synthase_ H+ transporting_ mitochondrial F1 complex_ beta polypeptide
513ATP5DATP synthase_ H+ transporting_ mitochondrial F1 complex_ delta subunit
515ATP5F1ATP synthase_ H+ transporting_ mitochondrial Fo complex_ subunit B1
523ATP6V1AATPase_ H+ transporting_ lysosomal 70kDa_ V1 subunit A
525ATP6V1B1ATPase_ H+ transporting_ lysosomal 56/58kDa_ V1 subunit B1
526ATP6V1B2ATPase_ H+ transporting_ lysosomal 56/58kDa_ V1 subunit B2
529ATP6V1E1ATPase_ H+ transporting_ lysosomal 31kDa_ V1 subunit E1
535ATP6V0A1ATPase_ H+ transporting_ lysosomal V0 subunit a1
538ATP7AATPase_ Cu++ transporting_ alpha polypeptide
581BAXBCL2-associated X protein
836CASP3caspase 3_ apoptosis-related cysteine peptidase
847CATcatalase
988CDC5LCDC5 cell division cycle 5-like (S. pombe)
1133CHRM5cholinergic receptor_ muscarinic 5
1385CREB1cAMP responsive element binding protein 1
1387CREBBPCREB binding protein
1499CTNNB1catenin (cadherin-associated protein)_ beta 1_ 88kDa
1659DHX8DEAH (Asp-Glu-Ala-His) box polypeptide 8
1785DNM2dynamin 2
1812DRD1dopamine receptor D1
1813DRD2dopamine receptor D2
1814DRD3dopamine receptor D3
1815DRD4dopamine receptor D4
1816DRD5dopamine receptor D5
1950EGFepidermal growth factor
2019EN1engrailed homeobox 1
2058EPRSglutamyl-prolyl-tRNA synthetase
2071ERCC3excision repair cross-complementing rodent repair deficiency_ complementation group 3 (xeroderma pigmentosum group B complementing)
2073ERCC5excision repair cross-complementing rodent repair deficiency_ complementation group 5
2237FEN1flap structure-specific endonuclease 1
2309FOXO3forkhead box O3
2521FUSFused in sarcoma
2547XRCC6X-ray repair complementing defective repair in Chinese hamster cells 6
2550GABBR1gamma-aminobutyric acid (GABA) B receptor_ 1
2648KAT2AK(lysine) acetyltransferase 2A
2668GDNFglial cell derived neurotrophic factor
2740GLP1Rglucagon-like peptide 1 receptor
2778GNASGNAS complex locus
2847MCHR1melanin-concentrating hormone receptor 1
2902GRIN1glutamate receptor_ ionotropic_ N-methyl D-aspartate 1
2909GRLF1glucocorticoid receptor DNA binding factor 1
2912GRM2glutamate receptor_ metabotropic 2
2913GRM3glutamate receptor_ metabotropic 3
2914GRM4glutamate receptor_ metabotropic 4
2917GRM7glutamate receptor_ metabotropic 7
2918GRM8glutamate receptor_ metabotropic 8
2931GSK3Aglycogen synthase kinase 3 alpha
2935GSPT1G1 to S phase transition 1
2956MSH6mutS homolog 6 (E. coli)
3065HDAC1histone deacetylase 1
3066HDAC2histone deacetylase 2
3084NRG1neuregulin 1
3091HIF1Ahypoxia inducible factor 1_ alpha subunit (basic helix-loop-helix transcription factor)
3092HIP1huntingtin interacting protein 1
3146HMGB1high-mobility group box 1
3148HMGB2high-mobility group box 2
3156HMGCR3-hydroxy-3-methylglutaryl-CoA reductase
3162HMOX1heme oxygenase (decycling) 1
3178HNRNPA1heterogeneous nuclear ribonucleoprotein A1
3297HSF1heat shock transcription factor 1
3299HSF4heat shock transcription factor 4
3351HTR1B5-hydroxytryptamine (serotonin) receptor 1B
3479IGF1insulin-like growth factor 1 (somatomedin C)
3551IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells_ kinase beta
3643INSRinsulin receptor
3646EIF3Eeukaryotic translation initiation factor 3_ subunit E
3654IRAK1interleukin-1 receptor-associated kinase 1
3718JAK3Janus kinase 3
3725JUNjun proto-oncogene
3727JUNDjun D proto-oncogene
4205MEF2Amyocyte enhancer factor 2A
4255MGMTO-6-methylguanine-DNA methyltransferase
4291MLF1myeloid leukemia factor 1
4294MAP3K10mitogen-activated protein kinase kinase kinase 10
4436MSH2mutS homolog 2_ colon cancer_ nonpolyposis type 1 (E. coli)
4437MSH3mutS homolog 3 (E. coli)
4521NUDT1nudix (nucleoside diphosphate linked moiety X)-type motif 1
4773NFATC2nuclear factor of activated T-cells_ cytoplasmic_ calcineurin-dependent 2
4780NFE2L2nuclear factor (erythroid-derived 2)-like 2
4790NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
4809NHP2L1NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
4899NRF1nuclear respiratory factor 1
4914NTRK1neurotrophic tyrosine kinase_ receptor_ type 1
4928NUP98nucleoporin 98kDa
4968OGG18-oxoguanine DNA glycosylase
4985OPRD1opioid receptor_ delta 1
4986OPRK1opioid receptor_ kappa 1
4987OPRL1opiate receptor-like 1
5032P2RY11purinergic receptor P2Y_ G-protein coupled_ 11
5216PFN1profilin 1
5356PLRG1pleiotropic regulator 1 (PRL1 homolog_ Arabidopsis)
5430POLR2Apolymerase (RNA) II (DNA directed) polypeptide A_ 220kDa
5431POLR2BPolymerase (RNA) II (DNA directed) polypeptide B_ 140kDa
5467PPARDperoxisome proliferator-activated receptor delta
5468PPARGperoxisome proliferator-activated receptor gamma
5557PRIM1primase_ DNA_ polypeptide 1 (49kDa)
5573PRKAR1Aprotein kinase_ cAMP-dependent_ regulatory_ type I_ alpha (tissue specific extinguisher 1)
5594MAPK1mitogen-activated protein kinase 1
5606MAP2K3mitogen-activated protein kinase kinase 3
5705PSMC5proteasome (prosome_ macropain) 26S subunit_ ATPase_ 5
5901RANRAN_ member RAS oncogene family
5976UPF1UPF1 regulator of nonsense transcripts homolog (yeast)
5978RESTRE1-silencing transcription factor
6096RORBRAR-related orphan receptor B
6125RPL5ribosomal protein L5
6128RPL6ribosomal protein L6
6129RPL7ribosomal protein L7
6154RPL26ribosomal protein L26
6188RPS3ribosomal protein S3
6209RPS15Ribosomal protein S15
6217RPS16ribosomal protein S16
6256RXRAretinoid X receptor_ alpha
6257RXRBretinoid X receptor_ beta
6258RXRGretinoid X receptor_ gamma
6311ATXN2ataxin 2
6597SMARCA4SWI/SNF related_ matrix associated_ actin dependent regulator of chromatin_ subfamily a_ member 4
6601SMARCC2SWI/SNF related_ matrix associated_ actin dependent regulator of chromatin_ subfamily c_ member 2
6628SNRPBsmall nuclear ribonucleoprotein polypeptides B and B1
6632SNRPD1small nuclear ribonucleoprotein D1 polypeptide 16kDa
6633SNRPD2small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
6634SNRPD3small nuclear ribonucleoprotein D3 polypeptide 18kDa
6636SNRPFsmall nuclear ribonucleoprotein polypeptide F
6637SNRPGsmall nuclear ribonucleoprotein polypeptide G
6647SOD1superoxide dismutase 1_ soluble
6667SP1Sp1 transcription factor
6720SREBF1sterol regulatory element binding transcription factor 1
6721SREBF2sterol regulatory element binding transcription factor 2
6749SSRP1structure specific recognition protein 1
6776STAT5Asignal transducer and activator of transcription 5A
6777STAT5Bsignal transducer and activator of transcription 5B
6829SUPT5Hsuppressor of Ty 5 homolog (S. cerevisiae)
6874TAF4TAF4 RNA polymerase II_ TATA box binding protein (TBP)-associated factor_ 135kDa
6875TAF4BTAF4b RNA polymerase II_ TATA box binding protein (TBP)-associated factor_ 105kDa
7029TFDP2transcription factor Dp-2 (E2F dimerization partner 2)
7067THRAthyroid hormone receptor_ alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog_ avian)
7068THRBthyroid hormone receptor_ beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2_ avian)
7157TP53tumor protein p53
7161TP73tumor protein p73
7251TSG101tumor susceptibility gene 101
7307U2AF1U2 small nuclear RNA auxiliary factor 1
7314UBBubiquitin B
7319UBE2Aubiquitin-conjugating enzyme E2A (RAD6 homolog)
7329UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog_ yeast)
7334UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog_ yeast)
7336UBE2V2ubiquitin-conjugating enzyme E2 variant 2
7341SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
7376NR1H2nuclear receptor subfamily 1_ group H_ member 2
7415VCPvalosin-containing protein
7469WHSC2Wolf-Hirschhorn syndrome candidate 2
7533YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein_ eta polypeptide
7637ZNF84zinc finger protein 84
7919BAT1DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
7936RDBPRD RNA binding protein
7942TFEBtranscription factor EB
8091HMGA2high mobility group AT-hook 2
8295TRRAPtransformation/transcription domain-associated protein
8517IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells_ kinase gamma
8520HAT1histone acetyltransferase 1
8564KMOkynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
8568RRP1ribosomal RNA processing 1 homolog (S. cerevisiae)
8622PDE8Bphosphodiesterase 8B
8654PDE5Aphosphodiesterase 5A_ cGMP-specific
8721EDF1endothelial differentiation-related factor 1
8767RIPK2receptor-interacting serine-threonine kinase 2
8841HDAC3histone deacetylase 3
8878SQSTM1sequestosome 1
8942KYNUkynureninase (L-kynurenine hydrolase)
9045RPL14ribosomal protein L14
9126SMC3Structural maintenance of chromosomes 3
9252RPS6KA5ribosomal protein S6 kinase_ 90kDa_ polypeptide 5
9343EFTUD2elongation factor Tu GTP binding domain containing 2
9439MED23mediator complex subunit 23
9525VPS4Bvacuolar protein sorting 4 homolog B (S. cerevisiae)
9572NR1D1nuclear receptor subfamily 1_ group D_ member 1
9611NCOR1nuclear receptor corepressor 1
9689BZW1basic leucine zipper and W2 domains 1
9734HDAC9histone deacetylase 9
9759HDAC4histone deacetylase 4
9869SETDB1SET domain_ bifurcated 1
9924PAN2PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
10013HDAC6histone deacetylase 6
10014HDAC5histone deacetylase 5
10049DNAJB6DnaJ (Hsp40) homolog_ subfamily B_ member 6
10056FARSBphenylalanyl-tRNA synthetase_ beta subunit
10062NR1H3nuclear receptor subfamily 1_ group H_ member 3
10113PREBprolactin regulatory element binding
10212DDX39DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
10262SF3B4splicing factor 3b_ subunit 4_ 49kDa
10476ATP5HATP synthase_ H+ transporting_ mitochondrial Fo complex_ subunit d
10487CAP1CAP_ adenylate cyclase-associated protein 1 (yeast)
10569SLU7SLU7 splicing factor homolog (S. cerevisiae)
10594PRPF8PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
10891PPARGC1Aperoxisome proliferator-activated receptor gamma_ coactivator 1 alpha
10915TCERG1transcription elongation regulator 1
10946SF3A3splicing factor 3a_ subunit 3_ 60kDa
10992SF3B2splicing factor 3b_ subunit 2_ 145kDa
11030RBPMSRNA binding protein with multiple splicing
11198SUPT16Hsuppressor of Ty 16 homolog (S. cerevisiae)
22933SIRT2sirtuin 2
22938SNW1SNW domain containing 1
23019CNOT1CCR4-NOT transcription complex_ subunit 1
23020SNRNP200small nuclear ribonucleoprotein 200kDa (U5)
23049SMG1SMG1 homolog_ phosphatidylinositol 3-kinase-related kinase (C. elegans)
23077MYCBP2MYC binding protein 2
23090ZNF423zinc finger protein 423
23144ZC3H3zinc finger CCCH-type containing 3
23381SMG5Smg-5 homolog_ nonsense mediated mRNA decay factor (C. elegans)
23389MED13Lmediator complex subunit 13-like
23408SIRT5sirtuin 5
23409SIRT4sirtuin 4
23410SIRT3sirtuin 3
23411SIRT1sirtuin 1
23450SF3B3splicing factor 3b_ subunit 3_ 130kDa
23451SF3B1splicing factor 3b_ subunit 1_ 155kDa
23481PES1pescadillo homolog 1_ containing BRCT domain (zebrafish)
23517SKIV2L2Superkiller viralicidic activity 2-like 2 (S. cerevisiae)
23560GTPBP4GTP binding protein 4
23636NUP62nucleoporin 62kDa
25788RAD54BRAD54 homolog B (S. cerevisiae)
25896INTS7integrator complex subunit 7
25920COBRA1cofactor of BRCA1
25942SIN3ASIN3 homolog A_ transcription regulator (yeast)
26019UPF2UPF2 regulator of nonsense transcripts homolog (yeast)
26121PRPF31PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae)
26173INTS1integrator complex subunit 1
27161EIF2C2Eukaryotic translation initiation factor 2C_ 2
27339PRPF19PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
51176LEF1lymphoid enhancer-binding factor 1
51340CRNKL1crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
51497TH1LTH1-like (Drosophila)
51547SIRT7sirtuin 7
51548SIRT6sirtuin 6
51564HDAC7histone deacetylase 7
51606ATP6V1HATPase_ H+ transporting_ lysosomal 50/57kDa_ V1 subunit H
51616TAF9BTAF9B RNA polymerase II_ TATA box binding protein (TBP)-associated factor_ 31kDa
51692CPSF3cleavage and polyadenylation specific factor 3_ 73kDa
51701NLKnemo-like kinase
53981CPSF2cleavage and polyadenylation specific factor 2_ 100kDa
54039PCBP3poly(rC) binding protein 3
54583EGLN1egl nine homolog 1 (C. elegans)
54623PAF1Paf1_ RNA polymerase II associated factor_ homolog (S. cerevisiae)
55081IFT57intraflagellar transport 57 homolog (Chlamydomonas)
55339WDR33WD repeat domain 33
55656INTS8integrator complex subunit 8
55756INTS9integrator complex subunit 9
55869HDAC8histone deacetylase 8