PFAM ID:GO:0007165
Term :signal transduction
Entrez Gene IDs are linked to their corresponding NCBI GenBank entry.
Gene symbols are linked to the entry for the gene in the HD Research CrossRoads database.
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Entrez Gene IDApproved SymbolApproved Name
16AARSalanyl-tRNA synthetase
41ACCN2acid-sensing (proton-gated) ion channel 1
107ADCY1adenylate cyclase 1 (brain)
116ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary)
117ADCYAP1R1adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
134ADORA1adenosine A1 receptor
135ADORA2Aadenosine A2a receptor
136ADORA2Badenosine A2b receptor
156ADRBK1adrenergic_ beta_ receptor kinase 1
157ADRBK2adrenergic_ beta_ receptor kinase 2
207AKT1v-akt murine thymoma viral oncogene homolog 1
208AKT2V-akt murine thymoma viral oncogene homolog 2
334APLP2amyloid beta (A4) precursor-like protein 2
348APOEapolipoprotein E
367ARandrogen receptor
378ARF4ADP-ribosylation factor 4
387RHOAras homolog gene family_ member A
573BAG1BCL2-associated athanogene
701BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)
726CAPN5calpain 5
834CASP1caspase 1_ apoptosis-related cysteine peptidase (interleukin 1_ beta_ convertase)
841CASP8caspase 8_ apoptosis-related cysteine peptidase
847CATcatalase
857CAV1caveolin 1_ caveolae protein_ 22kDa
859CAV3caveolin 3
875CBScystathionine-beta-synthase
1012CDH13cadherin 13_ H-cadherin (heart)
1020CDK5cyclin-dependent kinase 5
1072CFL1cofilin 1 (non-muscle)
1128CHRM1cholinergic receptor_ muscarinic 1
1129CHRM2cholinergic receptor_ muscarinic 2
1131CHRM3cholinergic receptor_ muscarinic 3
1132CHRM4cholinergic receptor_ muscarinic 4
1133CHRM5cholinergic receptor_ muscarinic 5
1147CHUKconserved helix-loop-helix ubiquitous kinase
1241LTB4Rleukotriene B4 receptor
1268CNR1Cannabinoid receptor 1 (brain)
1269CNR2cannabinoid receptor 2 (macrophage)
1270CNTFciliary neurotrophic factor
1385CREB1cAMP responsive element binding protein 1
1387CREBBPCREB binding protein
1457CSNK2A1casein kinase 2_ alpha 1 polypeptide
1460CSNK2Bcasein kinase 2_ beta polypeptide
1499CTNNB1catenin (cadherin-associated protein)_ beta 1_ 88kDa
1612DAPK1death-associated protein kinase 1
1613DAPK3death-associated protein kinase 3
1742DLG4discs_ large homolog 4 (Drosophila)
1785DNM2dynamin 2
1812DRD1dopamine receptor D1
1813DRD2dopamine receptor D2
1814DRD3dopamine receptor D3
1815DRD4dopamine receptor D4
1816DRD5dopamine receptor D5
1827RCAN1regulator of calcineurin 1
1950EGFepidermal growth factor
2057EPORerythropoietin receptor
2060EPS15epidermal growth factor receptor pathway substrate 15
2209FCGR1AFc fragment of IgG_ high affinity Ia_ receptor (CD64)
2237FEN1flap structure-specific endonuclease 1
2243FGAfibrinogen alpha chain
2247FGF2fibroblast growth factor 2 (basic)
2339FNTAfarnesyltransferase_ CAAX box_ alpha
2357FPR1formyl peptide receptor 1
2475MTORmechanistic target of rapamycin (serine/threonine kinase)
2550GABBR1gamma-aminobutyric acid (GABA) B receptor_ 1
2554GABRA1gamma-aminobutyric acid (GABA) A receptor_ alpha 1
2566GABRG2gamma-aminobutyric acid (GABA) A receptor_ gamma 2
2668GDNFglial cell derived neurotrophic factor
2674GFRA1GDNF family receptor alpha 1
2675GFRA2GDNF family receptor alpha 2
2676GFRA3GDNF family receptor alpha 3
2740GLP1Rglucagon-like peptide 1 receptor
2770GNAI1guanine nucleotide binding protein (G protein)_ alpha inhibiting activity polypeptide 1
2778GNASGNAS complex locus
2782GNB1guanine nucleotide binding protein (G protein)_ beta polypeptide 1
2798GNRHRgonadotropin-releasing hormone receptor
2810SFNstratifin
2826CCR10chemokine (C-C motif) receptor 10
2847MCHR1melanin-concentrating hormone receptor 1
2868GRK4G protein-coupled receptor kinase 4
2869GRK5G protein-coupled receptor kinase 5
2870GRK6G protein-coupled receptor kinase 6
2890GRIA1glutamate receptor_ ionotropic_ AMPA 1
2891GRIA2glutamate receptor_ ionotropic_ AMPA 2
2892GRIA3glutamate receptor_ ionotrophic_ AMPA 3
2893GRIA4glutamate receptor_ ionotrophic_ AMPA 4
2902GRIN1glutamate receptor_ ionotropic_ N-methyl D-aspartate 1
2903GRIN2Aglutamate receptor_ ionotropic_ N-methyl D-aspartate 2A
2904GRIN2Bglutamate receptor_ ionotropic_ N-methyl D-aspartate 2B
2905GRIN2Cglutamate receptor_ ionotropic_ N-methyl D-aspartate 2C
2906GRIN2Dglutamate receptor_ ionotropic_ N-methyl D-aspartate 2D
2909GRLF1glucocorticoid receptor DNA binding factor 1
2911GRM1glutamate receptor_ metabotropic 1
2912GRM2glutamate receptor_ metabotropic 2
2913GRM3glutamate receptor_ metabotropic 3
2914GRM4glutamate receptor_ metabotropic 4
2915GRM5glutamate receptor_ metabotropic 5
2916GRM6glutamate receptor_ metabotropic 6
2917GRM7glutamate receptor_ metabotropic 7
2918GRM8glutamate receptor_ metabotropic 8
2931GSK3Aglycogen synthase kinase 3 alpha
2932GSK3Bglycogen synthase kinase 3 beta
2956MSH6mutS homolog 6 (E. coli)
3060HCRThypocretin (orexin) neuropeptide precursor
3061HCRTR1hypocretin (orexin) receptor 1
3062HCRTR2hypocretin (orexin) receptor 2
3064HTThuntingtin
3084NRG1neuregulin 1
3091HIF1Ahypoxia inducible factor 1_ alpha subunit (basic helix-loop-helix transcription factor)
3146HMGB1high-mobility group box 1
3148HMGB2high-mobility group box 2
3162HMOX1heme oxygenase (decycling) 1
3301DNAJA1DnaJ (Hsp40) homolog_ subfamily A_ member 1
3309HSPA5heat shock 70kDa protein 5 (glucose-regulated protein_ 78kDa)
3320HSP90AA1heat shock protein 90kDa alpha (cytosolic)_ class A member 1
3350HTR1A5-hydroxytryptamine (serotonin) receptor 1A
3351HTR1B5-hydroxytryptamine (serotonin) receptor 1B
3355HTR1F5-hydroxytryptamine (serotonin) receptor 1F
3358HTR2C5-hydroxytryptamine (serotonin) receptor 2C
3362HTR65-hydroxytryptamine (serotonin) receptor 6
3363HTR75-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
3479IGF1insulin-like growth factor 1 (somatomedin C)
3570IL6Rinterleukin 6 receptor
3572IL6STinterleukin 6 signal transducer (gp130_ oncostatin M receptor)
3612IMPA1inositol(myo)-1(or 4)-monophosphatase 1
3643INSRinsulin receptor
3654IRAK1interleukin-1 receptor-associated kinase 1
3674ITGA2Bintegrin_ alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex_ antigen CD41)
3706ITPKAinositol 1_4_5-trisphosphate 3-kinase A
3708ITPR1inositol 1_4_5-triphosphate receptor_ type 1
3709ITPR2inositol 1_4_5-triphosphate receptor_ type 2
3710ITPR3inositol 1_4_5-triphosphate receptor_ type 3
3716JAK1Janus kinase 1
3717JAK2Janus kinase 2
3718JAK3Janus kinase 3
3725JUNjun proto-oncogene
3791KDRkinase insert domain receptor (a type III receptor tyrosine kinase)
3977LIFRleukemia inhibitory factor receptor alpha
4214MAP3K1mitogen-activated protein kinase kinase kinase 1
4217MAP3K5mitogen-activated protein kinase kinase kinase 5
4218RAB8ARAB8A_ member RAS oncogene family
4293MAP3K9mitogen-activated protein kinase kinase kinase 9
4294MAP3K10mitogen-activated protein kinase kinase kinase 10
4296MAP3K11mitogen-activated protein kinase kinase kinase 11
4301MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog_ Drosophila); translocated to_ 4
4436MSH2mutS homolog 2_ colon cancer_ nonpolyposis type 1 (E. coli)
4790NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
4803NGFnerve growth factor (beta polypeptide)
4852NPYneuropeptide Y
4902NRTNneurturin
4914NTRK1neurotrophic tyrosine kinase_ receptor_ type 1
4916NTRK3neurotrophic tyrosine kinase_ receptor_ type 3
4985OPRD1opioid receptor_ delta 1
4986OPRK1opioid receptor_ kappa 1
4987OPRL1opiate receptor-like 1
4988OPRM1opioid receptor_ mu 1
5023P2RX1purinergic receptor P2X_ ligand-gated ion channel_ 1
5024P2RX3purinergic receptor P2X_ ligand-gated ion channel_ 3
5025P2RX4purinergic receptor P2X_ ligand-gated ion channel_ 4
5026P2RX5purinergic receptor P2X_ ligand-gated ion channel_ 5
5027p2rx7purinergic receptor P2X_ ligand-gated ion channel_ 7
5028P2RY1purinergic receptor P2Y_ G-protein coupled_ 1
5029P2RY2purinergic receptor P2Y_ G-protein coupled_ 2
5030P2RY4pyrimidinergic receptor P2Y_ G-protein coupled_ 4
5031P2RY6pyrimidinergic receptor P2Y_ G-protein coupled_ 6
5032P2RY11purinergic receptor P2Y_ G-protein coupled_ 11
5058PAK1p21 protein (Cdc42/Rac)-activated kinase 1
5062pak2p21 protein (Cdc42/Rac)-activated kinase 2
5136PDE1Aphosphodiesterase 1A_ calmodulin-dependent
5138PDE2Aphosphodiesterase 2A_ cGMP-stimulated
5141PDE4Aphosphodiesterase 4A_ cAMP-specific
5142PDE4Bphosphodiesterase 4B_ cAMP-specific
5144PDE4Dphosphodiesterase 4D_ cAMP-specific
5286PIK3C2Aphosphoinositide-3-kinase_ class 2_ alpha polypeptide
5289PIK3C3phosphoinositide-3-kinase_ class 3
5290PIK3CAphosphoinositide-3-kinase_ catalytic_ alpha polypeptide
5291PIK3CBphosphoinositide-3-kinase_ catalytic_ beta polypeptide
5295PIK3R1phosphoinositide-3-kinase_ regulatory subunit 1 (alpha)
5296PIK3R2phosphoinositide-3-kinase_ regulatory subunit 2 (beta)
5300PIN1peptidylprolyl cis/trans isomerase_ NIMA-interacting 1
5467PPARDperoxisome proliferator-activated receptor delta
5468PPARGperoxisome proliferator-activated receptor gamma
5566PRKACAprotein kinase_ cAMP-dependent_ catalytic_ alpha
5567PRKACBprotein kinase_ cAMP-dependent_ catalytic_ beta
5568PRKACGprotein kinase_ cAMP-dependent_ catalytic_ gamma
5573PRKAR1Aprotein kinase_ cAMP-dependent_ regulatory_ type I_ alpha (tissue specific extinguisher 1)
5575PRKAR1Bprotein kinase_ cAMP-dependent_ regulatory_ type I_ beta
5576PRKAR2Aprotein kinase_ cAMP-dependent_ regulatory_ type II_ alpha
5577PRKAR2Bprotein kinase_ cAMP-dependent_ regulatory_ type II_ beta
5578PRKCAprotein kinase C_ alpha
5579PRKCBprotein kinase C_ beta
5580PRKCDprotein kinase C_ delta
5581PRKCEprotein kinase C_ epsilon
5586PKN2protein kinase N2
5590PRKCZProtein kinase C_ zeta
5594MAPK1mitogen-activated protein kinase 1
5595MAPK3mitogen-activated protein kinase 3
5599MAPK8mitogen-activated protein kinase 8
5601MAPK9mitogen-activated protein kinase 9
5602MAPK10mitogen-activated protein kinase 10
5604MAP2K1mitogen-activated protein kinase kinase 1
5605MAP2K2mitogen-activated protein kinase kinase 2
5606MAP2K3mitogen-activated protein kinase kinase 3
5608MAP2K6mitogen-activated protein kinase kinase 6
5663PSEN1presenilin 1
5664PSEN2presenilin 2 (Alzheimer disease 4)
5727PTCH1patched 1
5728PTENphosphatase and tensin homolog
5861RAB1ARAB1A_ member RAS oncogene family
5868RAB5ARAB5A_ member RAS oncogene family
5901RANRAN_ member RAS oncogene family
5912RAP2BRAP2B_ member of RAS oncogene family
6009RHEBRas homolog enriched in brain
6011GRK1G protein-coupled receptor kinase 1
6093ROCK1Rho-associated_ coiled-coil containing protein kinase 1
6198RPS6KB1ribosomal protein S6 kinase_ 70kDa_ polypeptide 1
6199RPS6KB2ribosomal protein S6 kinase_ 70kDa_ polypeptide 2
6256RXRAretinoid X receptor_ alpha
6352CCL5chemokine (C-C motif) ligand 5
6416MAP2K4mitogen-activated protein kinase kinase 4
6453ITSN1intersectin 1 (SH3 domain protein)
6457SH3GL3SH3-domain GRB2-like 3
6647SOD1superoxide dismutase 1_ soluble
6714SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
6776STAT5Asignal transducer and activator of transcription 5A
6777STAT5Bsignal transducer and activator of transcription 5B
6863TAC1tachykinin_ precursor 1
6866TAC3tachykinin 3
7052TGM2transglutaminase 2 (C polypeptide_ protein-glutamine-gamma-glutamyltransferase)
7067THRAthyroid hormone receptor_ alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog_ avian)
7099TLR4toll-like receptor 4
7157TP53tumor protein p53
7161TP73tumor protein p73
7188TRAF5TNF receptor-associated factor 5
7204TRIOtriple functional domain (PTPRF interacting)
7248TSC1tuberous sclerosis 1
7249TSC2tuberous sclerosis 2
7323UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog_ yeast)
7334UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog_ yeast)
7415VCPvalosin-containing protein
7422VEGFAvascular endothelial growth factor A
7531YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein_ epsilon polypeptide
7533YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein_ eta polypeptide
7534YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein_ zeta polypeptide
7855FZD5frizzled homolog 5 (Drosophila)
8239USP9Xubiquitin specific peptidase 9_ X-linked
8408ULK1unc-51-like kinase 1 (C. elegans)
8517IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells_ kinase gamma
8622PDE8Bphosphodiesterase 8B
8654PDE5Aphosphodiesterase 5A_ cGMP-specific
8660IRS2insulin receptor substrate 2
8729GBF1golgi brefeldin A resistant guanine nucleotide exchange factor 1
8766RAB11ARAB11A_ member RAS oncogene family
8767RIPK2receptor-interacting serine-threonine kinase 2
8797TNFRSF10Atumor necrosis factor receptor superfamily_ member 10a
8851CDK5R1cyclin-dependent kinase 5_ regulatory subunit 1 (p35)
8878SQSTM1sequestosome 1
8945BTRCbeta-transducin repeat containing
9022CLIC3chloride intracellular channel 3
9038TAAR5trace amine associated receptor 5
9126SMC3Structural maintenance of chromosomes 3
9230RAB11BRAB11B_ member RAS oncogene family
9241NOGnoggin
9252RPS6KA5ribosomal protein S6 kinase_ 90kDa_ polypeptide 5
9287TAAR2trace amine associated receptor 2
9288TAAR3trace amine associated receptor 3 (gene/pseudogene)
9459ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
9475ROCK2Rho-associated_ coiled-coil containing protein kinase 2
9479MAPK8IP1mitogen-activated protein kinase 8 interacting protein 1
9536PTGESprostaglandin E synthase
9637FEZ2fasciculation and elongation protein zeta 2 (zygin II)
9886RHOBTB1Rho-related BTB domain containing 1
9908G3BP2GTPase activating protein (SH3 domain) binding protein 2
9927MFN2mitofusin 2
9934P2RY14purinergic receptor P2Y_ G-protein coupled_ 14
10125RASGRP1RAS guanyl releasing protein 1 (calcium and DAG-regulated)
10133OPTNoptineurin
10273STUB1STIP1 homology and U-box containing protein 1_ E3 ubiquitin protein ligase
10342TFGTRK-fused gene
10411RAPGEF3Rap guanine nucleotide exchange factor (GEF) 3
10487CAP1CAP_ adenylate cyclase-associated protein 1 (yeast)
10846PDE10Aphosphodiesterase 10A
10891PPARGC1Aperoxisome proliferator-activated receptor gamma_ coactivator 1 alpha
11188NISCHnischarin
22858ICKintestinal cell (MAK-like) kinase
22953P2RX2purinergic receptor P2X_ ligand-gated ion channel_ 2
23390ZDHHC17zinc finger_ DHHC-type containing 17
23411SIRT1sirtuin 1
23551RASD2RASD family_ member 2
23604DAPK2death-associated protein kinase 2
23636NUP62nucleoporin 62kDa
23647ARFIP2ADP-ribosylation factor interacting protein 2
26750RPS6KC1ribosomal protein S6 kinase_ 52kDa_ polypeptide 1
29888STRN4striatin_ calmodulin binding protein 4
50506DUOX2dual oxidase 2
50618ITSN2intersectin 2
51176LEF1lymphoid enhancer-binding factor 1
51196PLCE1Phospholipase C_ epsilon 1
51701NLKnemo-like kinase
53829P2RY13purinergic receptor P2Y_ G-protein coupled_ 13
54503ZDHHC13zinc finger_ DHHC-type containing 13
55114ARHGAP17Rho GTPase activating protein 17
55647RAB20RAB20_ member RAS oncogene family
55803ADAP2ArfGAP with dual PH domains 2
56033BARX1BARX homeobox 1
56848SPHK2sphingosine kinase 2
59343SENP2SUMO1/sentrin/SMT3 specific peptidase 2
64805P2RY12purinergic receptor P2Y_ G-protein coupled_ 12
83551TAAR8trace amine associated receptor 8
84539MCHR2melanin-concentrating hormone receptor 2
112398EGLN2egl nine homolog 2 (C. elegans)
116444GRIN3Bglutamate receptor_ ionotropic_ N-methyl-D-aspartate 3B
120329CASP12caspase 12 (gene/pseudogene)
131890GRK7G protein-coupled receptor kinase 7
133522PPARGC1Bperoxisome proliferator-activated receptor gamma_ coactivator 1 beta
134860TAAR9trace amine associated receptor 9 (gene/pseudogene)
134864TAAR1trace amine associated receptor 1
266743NPAS4neuronal PAS domain protein 4
286530P2RY8purinergic receptor P2Y_ G-protein coupled_ 8
319100TAAR6trace amine associated receptor 6