PFAM ID:GO:0007242
Term :intracellular signaling cascade
Entrez Gene IDs are linked to their corresponding NCBI GenBank entry.
Gene symbols are linked to the entry for the gene in the HD Research CrossRoads database.
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Entrez Gene IDApproved SymbolApproved Name
16AARSalanyl-tRNA synthetase
107ADCY1adenylate cyclase 1 (brain)
135ADORA2Aadenosine A2a receptor
136ADORA2Badenosine A2b receptor
207AKT1v-akt murine thymoma viral oncogene homolog 1
348APOEapolipoprotein E
367ARandrogen receptor
378ARF4ADP-ribosylation factor 4
387RHOAras homolog gene family_ member A
701BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)
834CASP1caspase 1_ apoptosis-related cysteine peptidase (interleukin 1_ beta_ convertase)
841CASP8caspase 8_ apoptosis-related cysteine peptidase
847CATcatalase
857CAV1caveolin 1_ caveolae protein_ 22kDa
859CAV3caveolin 3
875CBScystathionine-beta-synthase
1012CDH13cadherin 13_ H-cadherin (heart)
1020CDK5cyclin-dependent kinase 5
1072CFL1cofilin 1 (non-muscle)
1128CHRM1cholinergic receptor_ muscarinic 1
1129CHRM2cholinergic receptor_ muscarinic 2
1133CHRM5cholinergic receptor_ muscarinic 5
1147CHUKconserved helix-loop-helix ubiquitous kinase
1241LTB4Rleukotriene B4 receptor
1268CNR1Cannabinoid receptor 1 (brain)
1269CNR2cannabinoid receptor 2 (macrophage)
1270CNTFciliary neurotrophic factor
1499CTNNB1catenin (cadherin-associated protein)_ beta 1_ 88kDa
1612DAPK1death-associated protein kinase 1
1613DAPK3death-associated protein kinase 3
1812DRD1dopamine receptor D1
1813DRD2dopamine receptor D2
1814DRD3dopamine receptor D3
1815DRD4dopamine receptor D4
1816DRD5dopamine receptor D5
1827RCAN1regulator of calcineurin 1
1950EGFepidermal growth factor
2237FEN1flap structure-specific endonuclease 1
2247FGF2fibroblast growth factor 2 (basic)
2357FPR1formyl peptide receptor 1
2475MTORmechanistic target of rapamycin (serine/threonine kinase)
2740GLP1Rglucagon-like peptide 1 receptor
2778GNASGNAS complex locus
2782GNB1guanine nucleotide binding protein (G protein)_ beta polypeptide 1
2810SFNstratifin
2847MCHR1melanin-concentrating hormone receptor 1
2869GRK5G protein-coupled receptor kinase 5
2904GRIN2Bglutamate receptor_ ionotropic_ N-methyl D-aspartate 2B
2914GRM4glutamate receptor_ metabotropic 4
2915GRM5glutamate receptor_ metabotropic 5
2932GSK3Bglycogen synthase kinase 3 beta
2956MSH6mutS homolog 6 (E. coli)
3062HCRTR2hypocretin (orexin) receptor 2
3148HMGB2high-mobility group box 2
3162HMOX1heme oxygenase (decycling) 1
3301DNAJA1DnaJ (Hsp40) homolog_ subfamily A_ member 1
3309HSPA5heat shock 70kDa protein 5 (glucose-regulated protein_ 78kDa)
3351HTR1B5-hydroxytryptamine (serotonin) receptor 1B
3355HTR1F5-hydroxytryptamine (serotonin) receptor 1F
3358HTR2C5-hydroxytryptamine (serotonin) receptor 2C
3362HTR65-hydroxytryptamine (serotonin) receptor 6
3363HTR75-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
3479IGF1insulin-like growth factor 1 (somatomedin C)
3570IL6Rinterleukin 6 receptor
3572IL6STinterleukin 6 signal transducer (gp130_ oncostatin M receptor)
3643INSRinsulin receptor
3654IRAK1interleukin-1 receptor-associated kinase 1
3716JAK1Janus kinase 1
3717JAK2Janus kinase 2
3718JAK3Janus kinase 3
4214MAP3K1mitogen-activated protein kinase kinase kinase 1
4217MAP3K5mitogen-activated protein kinase kinase kinase 5
4218RAB8ARAB8A_ member RAS oncogene family
4293MAP3K9mitogen-activated protein kinase kinase kinase 9
4294MAP3K10mitogen-activated protein kinase kinase kinase 10
4296MAP3K11mitogen-activated protein kinase kinase kinase 11
4436MSH2mutS homolog 2_ colon cancer_ nonpolyposis type 1 (E. coli)
4803NGFnerve growth factor (beta polypeptide)
4852NPYneuropeptide Y
4902NRTNneurturin
4914NTRK1neurotrophic tyrosine kinase_ receptor_ type 1
4985OPRD1opioid receptor_ delta 1
4986OPRK1opioid receptor_ kappa 1
4987OPRL1opiate receptor-like 1
4988OPRM1opioid receptor_ mu 1
5024P2RX3purinergic receptor P2X_ ligand-gated ion channel_ 3
5025P2RX4purinergic receptor P2X_ ligand-gated ion channel_ 4
5026P2RX5purinergic receptor P2X_ ligand-gated ion channel_ 5
5027p2rx7purinergic receptor P2X_ ligand-gated ion channel_ 7
5028P2RY1purinergic receptor P2Y_ G-protein coupled_ 1
5029P2RY2purinergic receptor P2Y_ G-protein coupled_ 2
5030P2RY4pyrimidinergic receptor P2Y_ G-protein coupled_ 4
5031P2RY6pyrimidinergic receptor P2Y_ G-protein coupled_ 6
5032P2RY11purinergic receptor P2Y_ G-protein coupled_ 11
5058PAK1p21 protein (Cdc42/Rac)-activated kinase 1
5286PIK3C2Aphosphoinositide-3-kinase_ class 2_ alpha polypeptide
5289PIK3C3phosphoinositide-3-kinase_ class 3
5290PIK3CAphosphoinositide-3-kinase_ catalytic_ alpha polypeptide
5291PIK3CBphosphoinositide-3-kinase_ catalytic_ beta polypeptide
5295PIK3R1phosphoinositide-3-kinase_ regulatory subunit 1 (alpha)
5467PPARDperoxisome proliferator-activated receptor delta
5566PRKACAprotein kinase_ cAMP-dependent_ catalytic_ alpha
5567PRKACBprotein kinase_ cAMP-dependent_ catalytic_ beta
5568PRKACGprotein kinase_ cAMP-dependent_ catalytic_ gamma
5573PRKAR1Aprotein kinase_ cAMP-dependent_ regulatory_ type I_ alpha (tissue specific extinguisher 1)
5575PRKAR1Bprotein kinase_ cAMP-dependent_ regulatory_ type I_ beta
5576PRKAR2Aprotein kinase_ cAMP-dependent_ regulatory_ type II_ alpha
5577PRKAR2Bprotein kinase_ cAMP-dependent_ regulatory_ type II_ beta
5578PRKCAprotein kinase C_ alpha
5579PRKCBprotein kinase C_ beta
5580PRKCDprotein kinase C_ delta
5581PRKCEprotein kinase C_ epsilon
5590PRKCZProtein kinase C_ zeta
5594MAPK1mitogen-activated protein kinase 1
5595MAPK3mitogen-activated protein kinase 3
5599MAPK8mitogen-activated protein kinase 8
5601MAPK9mitogen-activated protein kinase 9
5602MAPK10mitogen-activated protein kinase 10
5604MAP2K1mitogen-activated protein kinase kinase 1
5605MAP2K2mitogen-activated protein kinase kinase 2
5606MAP2K3mitogen-activated protein kinase kinase 3
5608MAP2K6mitogen-activated protein kinase kinase 6
5663PSEN1presenilin 1
5664PSEN2presenilin 2 (Alzheimer disease 4)
5728PTENphosphatase and tensin homolog
5861RAB1ARAB1A_ member RAS oncogene family
5868RAB5ARAB5A_ member RAS oncogene family
5901RANRAN_ member RAS oncogene family
5912RAP2BRAP2B_ member of RAS oncogene family
6009RHEBRas homolog enriched in brain
6093ROCK1Rho-associated_ coiled-coil containing protein kinase 1
6199RPS6KB2ribosomal protein S6 kinase_ 70kDa_ polypeptide 2
6256RXRAretinoid X receptor_ alpha
6416MAP2K4mitogen-activated protein kinase kinase 4
6453ITSN1intersectin 1 (SH3 domain protein)
6647SOD1superoxide dismutase 1_ soluble
6714SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
6776STAT5Asignal transducer and activator of transcription 5A
6777STAT5Bsignal transducer and activator of transcription 5B
7052TGM2transglutaminase 2 (C polypeptide_ protein-glutamine-gamma-glutamyltransferase)
7067THRAthyroid hormone receptor_ alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog_ avian)
7099TLR4toll-like receptor 4
7157TP53tumor protein p53
7161TP73tumor protein p73
7188TRAF5TNF receptor-associated factor 5
7204TRIOtriple functional domain (PTPRF interacting)
7248TSC1tuberous sclerosis 1
7249TSC2tuberous sclerosis 2
7334UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog_ yeast)
7415VCPvalosin-containing protein
7531YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein_ epsilon polypeptide
7533YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein_ eta polypeptide
8408ULK1unc-51-like kinase 1 (C. elegans)
8517IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells_ kinase gamma
8729GBF1golgi brefeldin A resistant guanine nucleotide exchange factor 1
8766RAB11ARAB11A_ member RAS oncogene family
8767RIPK2receptor-interacting serine-threonine kinase 2
8797TNFRSF10Atumor necrosis factor receptor superfamily_ member 10a
8878SQSTM1sequestosome 1
9230RAB11BRAB11B_ member RAS oncogene family
9252RPS6KA5ribosomal protein S6 kinase_ 90kDa_ polypeptide 5
9459ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
9475ROCK2Rho-associated_ coiled-coil containing protein kinase 2
9479MAPK8IP1mitogen-activated protein kinase 8 interacting protein 1
9886RHOBTB1Rho-related BTB domain containing 1
9908G3BP2GTPase activating protein (SH3 domain) binding protein 2
9927MFN2mitofusin 2
10125RASGRP1RAS guanyl releasing protein 1 (calcium and DAG-regulated)
10342TFGTRK-fused gene
10411RAPGEF3Rap guanine nucleotide exchange factor (GEF) 3
10891PPARGC1Aperoxisome proliferator-activated receptor gamma_ coactivator 1 alpha
11188NISCHnischarin
22858ICKintestinal cell (MAK-like) kinase
22953P2RX2purinergic receptor P2X_ ligand-gated ion channel_ 2
23390ZDHHC17zinc finger_ DHHC-type containing 17
23411SIRT1sirtuin 1
23551RASD2RASD family_ member 2
23604DAPK2death-associated protein kinase 2
23636NUP62nucleoporin 62kDa
23647ARFIP2ADP-ribosylation factor interacting protein 2
50618ITSN2intersectin 2
51196PLCE1Phospholipase C_ epsilon 1
51701NLKnemo-like kinase
54503ZDHHC13zinc finger_ DHHC-type containing 13
55647RAB20RAB20_ member RAS oncogene family
55803ADAP2ArfGAP with dual PH domains 2
64805P2RY12purinergic receptor P2Y_ G-protein coupled_ 12
112398EGLN2egl nine homolog 2 (C. elegans)
120329CASP12caspase 12 (gene/pseudogene)
133522PPARGC1Bperoxisome proliferator-activated receptor gamma_ coactivator 1 beta