PFAM ID:GO:0019538
Term :protein metabolic process
Entrez Gene IDs are linked to their corresponding NCBI GenBank entry.
Gene symbols are linked to the entry for the gene in the HD Research CrossRoads database.
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Entrez Gene IDApproved SymbolApproved Name
16AARSalanyl-tRNA synthetase
118ADD1adducin 1 (alpha)
136ADORA2Badenosine A2b receptor
156ADRBK1adrenergic_ beta_ receptor kinase 1
157ADRBK2adrenergic_ beta_ receptor kinase 2
207AKT1v-akt murine thymoma viral oncogene homolog 1
208AKT2V-akt murine thymoma viral oncogene homolog 2
331XIAPX-linked inhibitor of apoptosis
348APOEapolipoprotein E
444ASPHaspartate beta-hydroxylase
538ATP7AATPase_ Cu++ transporting_ alpha polypeptide
596BCL2B-cell CLL/lymphoma 2
701BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)
726CAPN5calpain 5
823CAPN1calpain 1_ (mu/I) large subunit
824CAPN2calpain 2_ (m/II) large subunit
834CASP1caspase 1_ apoptosis-related cysteine peptidase (interleukin 1_ beta_ convertase)
835CASP2caspase 2_ apoptosis-related cysteine peptidase
836CASP3caspase 3_ apoptosis-related cysteine peptidase
839CASP6caspase 6_ apoptosis-related cysteine peptidase
840CASP7caspase 7_ apoptosis-related cysteine peptidase
841CASP8caspase 8_ apoptosis-related cysteine peptidase
842CASP9caspase 9_ apoptosis-related cysteine peptidase
847CATcatalase
859CAV3caveolin 3
875CBScystathionine-beta-synthase
891CCNB1cyclin B1
908CCT6Achaperonin containing TCP1_ subunit 6A (zeta 1)
1020CDK5cyclin-dependent kinase 5
1072CFL1cofilin 1 (non-muscle)
1128CHRM1cholinergic receptor_ muscarinic 1
1131CHRM3cholinergic receptor_ muscarinic 3
1147CHUKconserved helix-loop-helix ubiquitous kinase
1270CNTFciliary neurotrophic factor
1385CREB1cAMP responsive element binding protein 1
1387CREBBPCREB binding protein
1410CRYABcrystallin_ alpha B
1457CSNK2A1casein kinase 2_ alpha 1 polypeptide
1499CTNNB1catenin (cadherin-associated protein)_ beta 1_ 88kDa
1508CTSBcathepsin B
1509CTSDcathepsin D
1514CTSL1cathepsin L1
1612DAPK1death-associated protein kinase 1
1613DAPK3death-associated protein kinase 3
1636ACEangiotensin I converting enzyme (peptidyl-dipeptidase A) 1
1815DRD4dopamine receptor D4
1847DUSP5dual specificity phosphatase 5
1849DUSP7dual specificity phosphatase 7
1917EEF1A2eukaryotic translation elongation factor 1 alpha 2
1938EEF2eukaryotic translation elongation factor 2
1950EGFepidermal growth factor
1968EIF2S3eukaryotic translation initiation factor 2_ subunit 3 gamma_ 52kDa
1983EIF5eukaryotic translation initiation factor 5
2058EPRSglutamyl-prolyl-tRNA synthetase
2107ETF1eukaryotic translation termination factor 1
2247FGF2fibroblast growth factor 2 (basic)
2339FNTAfarnesyltransferase_ CAAX box_ alpha
2342FNTBFarnesyltransferase_ CAAX box_ beta
2357FPR1formyl peptide receptor 1
2444FRKfyn-related kinase
2475MTORmechanistic target of rapamycin (serine/threonine kinase)
2648KAT2AK(lysine) acetyltransferase 2A
2868GRK4G protein-coupled receptor kinase 4
2869GRK5G protein-coupled receptor kinase 5
2870GRK6G protein-coupled receptor kinase 6
2891GRIA2glutamate receptor_ ionotropic_ AMPA 2
2903GRIN2Aglutamate receptor_ ionotropic_ N-methyl D-aspartate 2A
2914GRM4glutamate receptor_ metabotropic 4
2931GSK3Aglycogen synthase kinase 3 alpha
2932GSK3Bglycogen synthase kinase 3 beta
2935GSPT1G1 to S phase transition 1
3065HDAC1histone deacetylase 1
3066HDAC2histone deacetylase 2
3091HIF1Ahypoxia inducible factor 1_ alpha subunit (basic helix-loop-helix transcription factor)
3093UBE2Kubiquitin-conjugating enzyme E2K (UBC1 homolog_ yeast)
3299HSF4heat shock transcription factor 4
3300DNAJB2DnaJ (Hsp40) homolog_ subfamily B_ member 2
3301DNAJA1DnaJ (Hsp40) homolog_ subfamily A_ member 1
3312HSPA8heat shock 70kDa protein 8
3313HSPA9heat shock 70kDa protein 9 (mortalin)
3315HSPB1heat shock 27kDa protein 1
3320HSP90AA1heat shock protein 90kDa alpha (cytosolic)_ class A member 1
3337DNAJB1DnaJ (Hsp40) homolog_ subfamily B_ member 1
3479IGF1insulin-like growth factor 1 (somatomedin C)
3551IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells_ kinase beta
3570IL6Rinterleukin 6 receptor
3572IL6STinterleukin 6 signal transducer (gp130_ oncostatin M receptor)
3643INSRinsulin receptor
3646EIF3Eeukaryotic translation initiation factor 3_ subunit E
3654IRAK1interleukin-1 receptor-associated kinase 1
3716JAK1Janus kinase 1
3717JAK2Janus kinase 2
3718JAK3Janus kinase 3
3725JUNjun proto-oncogene
3791KDRkinase insert domain receptor (a type III receptor tyrosine kinase)
3818KLKB1kallikrein B_ plasma (Fletcher factor) 1
3921RPSAribosomal protein SA
4214MAP3K1mitogen-activated protein kinase kinase kinase 1
4217MAP3K5mitogen-activated protein kinase kinase kinase 5
4293MAP3K9mitogen-activated protein kinase kinase kinase 9
4294MAP3K10mitogen-activated protein kinase kinase kinase 10
4296MAP3K11mitogen-activated protein kinase kinase kinase 11
4319MMP10matrix metallopeptidase 10 (stromelysin 2)
4323MMP14matrix metallopeptidase 14 (membrane-inserted)
4790NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
4803NGFnerve growth factor (beta polypeptide)
4905NSFN-ethylmaleimide-sensitive factor
4914NTRK1neurotrophic tyrosine kinase_ receptor_ type 1
4916NTRK3neurotrophic tyrosine kinase_ receptor_ type 3
5058PAK1p21 protein (Cdc42/Rac)-activated kinase 1
5062pak2p21 protein (Cdc42/Rac)-activated kinase 2
5071PARK2parkinson protein 2_ E3 ubiquitin protein ligase (parkin)
5190PEX6peroxisomal biogenesis factor 6
5217PFN2profilin 2
5289PIK3C3phosphoinositide-3-kinase_ class 3
5290PIK3CAphosphoinositide-3-kinase_ catalytic_ alpha polypeptide
5291PIK3CBphosphoinositide-3-kinase_ catalytic_ beta polypeptide
5295PIK3R1phosphoinositide-3-kinase_ regulatory subunit 1 (alpha)
5300PIN1peptidylprolyl cis/trans isomerase_ NIMA-interacting 1
5347PLK1polo-like kinase 1
5481PPIDpeptidylprolyl isomerase D
5495PPM1Bprotein phosphatase_ Mg2+/Mn2+ dependent_ 1B
5499PPP1CAprotein phosphatase 1_ catalytic subunit_ alpha isozyme
5530PPP3CAprotein phosphatase 3_ catalytic subunit_ alpha isozyme
5566PRKACAprotein kinase_ cAMP-dependent_ catalytic_ alpha
5567PRKACBprotein kinase_ cAMP-dependent_ catalytic_ beta
5568PRKACGprotein kinase_ cAMP-dependent_ catalytic_ gamma
5573PRKAR1Aprotein kinase_ cAMP-dependent_ regulatory_ type I_ alpha (tissue specific extinguisher 1)
5575PRKAR1Bprotein kinase_ cAMP-dependent_ regulatory_ type I_ beta
5576PRKAR2Aprotein kinase_ cAMP-dependent_ regulatory_ type II_ alpha
5577PRKAR2Bprotein kinase_ cAMP-dependent_ regulatory_ type II_ beta
5578PRKCAprotein kinase C_ alpha
5579PRKCBprotein kinase C_ beta
5580PRKCDprotein kinase C_ delta
5581PRKCEprotein kinase C_ epsilon
5586PKN2protein kinase N2
5590PRKCZProtein kinase C_ zeta
5594MAPK1mitogen-activated protein kinase 1
5595MAPK3mitogen-activated protein kinase 3
5599MAPK8mitogen-activated protein kinase 8
5601MAPK9mitogen-activated protein kinase 9
5602MAPK10mitogen-activated protein kinase 10
5604MAP2K1mitogen-activated protein kinase kinase 1
5605MAP2K2mitogen-activated protein kinase kinase 2
5606MAP2K3mitogen-activated protein kinase kinase 3
5608MAP2K6mitogen-activated protein kinase kinase 6
5655KLK10kallikrein-related peptidase 10
5663PSEN1presenilin 1
5664PSEN2presenilin 2 (Alzheimer disease 4)
5682PSMA1proteasome (prosome_ macropain) subunit_ alpha type_ 1
5686PSMA5proteasome (prosome_ macropain) subunit_ alpha type_ 5
5688PSMA7proteasome (prosome_ macropain) subunit_ alpha type_ 7
5690PSMB2proteasome (prosome_ macropain) subunit_ beta type_ 2
5691PSMB3proteasome (prosome_ macropain) subunit_ beta type_ 3
5693PSMB5proteasome (prosome_ macropain) subunit_ beta type_ 5
5694PSMB6proteasome (prosome_ macropain) subunit_ beta type_ 6
5695PSMB7proteasome (prosome_ macropain) subunit_ beta type_ 7
5701PSMC2proteasome (prosome_ macropain) 26S subunit_ ATPase_ 2
5702PSMC3proteasome (prosome_ macropain) 26S subunit_ ATPase_ 3
5705PSMC5proteasome (prosome_ macropain) 26S subunit_ ATPase_ 5
5706PSMC6proteasome (prosome_ macropain) 26S subunit_ ATPase_ 6
5708PSMD2proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 2
5709PSMD3proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 3
5710PSMD4proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 4
5713PSMD7proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 7
5714PSMD8proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 8
5717PSMD11proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 11
5727PTCH1patched 1
5728PTENphosphatase and tensin homolog
5903RANBP2RAN binding protein 2
5976UPF1UPF1 regulator of nonsense transcripts homolog (yeast)
6011GRK1G protein-coupled receptor kinase 1
6093ROCK1Rho-associated_ coiled-coil containing protein kinase 1
6125RPL5ribosomal protein L5
6128RPL6ribosomal protein L6
6129RPL7ribosomal protein L7
6130RPL7Aribosomal protein L7a
6132RPL8ribosomal protein L8
6137RPL13Ribosomal protein L13
6138RPL15ribosomal protein L15
6139RPL17ribosomal protein L17
6141RPL18ribosomal protein L18
6142RPL18Aribosomal protein L18a
6143RPL19ribosomal protein L19
6146RPL22ribosomal protein L22
6152RPL24ribosomal protein L24
6154RPL26ribosomal protein L26
6160RPL31ribosomal protein L31
6170RPL39ribosomal protein L39
6175RPLP0ribosomal protein_ large_ P0
6187RPS2ribosomal protein S2
6188RPS3ribosomal protein S3
6189RPS3Aribosomal protein S3A
6193RPS5ribosomal protein S5
6198RPS6KB1ribosomal protein S6 kinase_ 70kDa_ polypeptide 1
6199RPS6KB2ribosomal protein S6 kinase_ 70kDa_ polypeptide 2
6204RPS10ribosomal protein S10
6206RPS12ribosomal protein S12
6209RPS15Ribosomal protein S15
6217RPS16ribosomal protein S16
6222RPS18ribosomal protein S18
6227RPS21ribosomal protein S21
6311ATXN2ataxin 2
6416MAP2K4mitogen-activated protein kinase kinase 4
6477SIAH1seven in absentia homolog 1 (Drosophila)
6500SKP1S-phase kinase-associated protein 1
6612SUMO3SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
6647SOD1superoxide dismutase 1_ soluble
6714SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
6776STAT5Asignal transducer and activator of transcription 5A
6950TCP1t-complex 1
7052TGM2transglutaminase 2 (C polypeptide_ protein-glutamine-gamma-glutamyltransferase)
7078TIMP3TIMP metallopeptidase inhibitor 3
7204TRIOtriple functional domain (PTPRF interacting)
7248TSC1tuberous sclerosis 1
7251TSG101tumor susceptibility gene 101
7266DNAJC7DnaJ (Hsp40) homolog_ subfamily C_ member 7
7314UBBubiquitin B
7317UBA1ubiquitin-like modifier activating enzyme 1
7319UBE2Aubiquitin-conjugating enzyme E2A (RAD6 homolog)
7322UBE2D2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog_ yeast)
7323UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog_ yeast)
7328UBE2Hubiquitin-conjugating enzyme E2H (UBC8 homolog_ yeast)
7329UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog_ yeast)
7334UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog_ yeast)
7336UBE2V2ubiquitin-conjugating enzyme E2 variant 2
7337UBE3Aubiquitin protein ligase E3A
7341SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
7345UCHL1Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
7347UCHL3ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
7353UFD1Lubiquitin fusion degradation 1 like (yeast)
7376NR1H2nuclear receptor subfamily 1_ group H_ member 2
7415VCPvalosin-containing protein
7531YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein_ epsilon polypeptide
8239USP9Xubiquitin specific peptidase 9_ X-linked
8295TRRAPtransformation/transcription domain-associated protein
8408ULK1unc-51-like kinase 1 (C. elegans)
8453CUL2cullin 2
8454CUL1cullin 1
8510MMP23Bmatrix metallopeptidase 23B
8520HAT1histone acetyltransferase 1
8661EIF3Aeukaryotic translation initiation factor 3_ subunit A
8662EIF3Beukaryotic translation initiation factor 3_ subunit B
8668EIF3Ieukaryotic translation initiation factor 3_ subunit I
8767RIPK2receptor-interacting serine-threonine kinase 2
8841HDAC3histone deacetylase 3
8878SQSTM1sequestosome 1
8894EIF2S2eukaryotic translation initiation factor 2_ subunit 2 beta_ 38kDa
8898MTMR2myotubularin related protein 2
8945BTRCbeta-transducin repeat containing
9045RPL14ribosomal protein L14
9049AIParyl hydrocarbon receptor interacting protein
9184BUB3budding uninhibited by benzimidazoles 3 homolog (yeast)
9252RPS6KA5ribosomal protein S6 kinase_ 90kDa_ polypeptide 5
9349RPL23ribosomal protein L23
9474ATG5ATG5 autophagy related 5 homolog (S. cerevisiae)
9475ROCK2Rho-associated_ coiled-coil containing protein kinase 2
9531BAG3BCL2-associated athanogene 3
9730VPRBPVpr (HIV-1) binding protein
9734HDAC9histone deacetylase 9
9759HDAC4histone deacetylase 4
9924PAN2PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
10013HDAC6histone deacetylase 6
10049DNAJB6DnaJ (Hsp40) homolog_ subfamily B_ member 6
10054UBA2ubiquitin-like modifier activating enzyme 2
10055SAE1SUMO1 activating enzyme subunit 1
10056FARSBphenylalanyl-tRNA synthetase_ beta subunit
10062NR1H3nuclear receptor subfamily 1_ group H_ member 3
10105PPIFpeptidylprolyl isomerase F
10109ARPC2actin related protein 2/3 complex_ subunit 2_ 34kDa
10197PSME3proteasome (prosome_ macropain) activator subunit 3 (PA28 gamma; Ki)
10213PSMD14proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 14
10273STUB1STIP1 homology and U-box containing protein 1_ E3 ubiquitin protein ligase
10294DNAJA2DnaJ (Hsp40) homolog_ subfamily A_ member 2
10411RAPGEF3Rap guanine nucleotide exchange factor (GEF) 3
10533ATG7ATG7 autophagy related 7 homolog (S. cerevisiae)
10574CCT7chaperonin containing TCP1_ subunit 7 (eta)
10575CCT4chaperonin containing TCP1_ subunit 4 (delta)
10576CCT2chaperonin containing TCP1_ subunit 2 (beta)
10891PPARGC1Aperoxisome proliferator-activated receptor gamma_ coactivator 1 alpha
10939AFG3L2AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
11012KLK11kallikrein-related peptidase 11
11080DNAJB4DnaJ (Hsp40) homolog_ subfamily B_ member 4
11224RPL35ribosomal protein L35
22848AAK1AP2 associated kinase 1
22858ICKintestinal cell (MAK-like) kinase
22929SEPHS1selenophosphate synthetase 1
22933SIRT2sirtuin 2
22948CCT5chaperonin containing TCP1_ subunit 5 (epsilon)
23049SMG1SMG1 homolog_ phosphatidylinositol 3-kinase-related kinase (C. elegans)
23077MYCBP2MYC binding protein 2
23369PUM2pumilio homolog 2 (Drosophila)
23390ZDHHC17zinc finger_ DHHC-type containing 17
23408SIRT5sirtuin 5
23409SIRT4sirtuin 4
23410SIRT3sirtuin 3
23411SIRT1sirtuin 1
23560GTPBP4GTP binding protein 4
23604DAPK2death-associated protein kinase 2
25825BACE2beta-site APP-cleaving enzyme 2
26260FBXO25F-box protein 25
26750RPS6KC1ribosomal protein S6 kinase_ 52kDa_ polypeptide 1
27161EIF2C2Eukaryotic translation initiation factor 2C_ 2
27339PRPF19PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
27429HTRA2HtrA serine peptidase 2
28972SPCS1signal peptidase complex subunit 1 homolog (S. cerevisiae)
29959NRBP1nuclear receptor binding protein 1
30849PIK3R4phosphoinositide-3-kinase_ regulatory subunit 4
51160VPS28vacuolar protein sorting 28 homolog (S. cerevisiae)
51196PLCE1Phospholipase C_ epsilon 1
51343FZR1fizzy/cell division cycle 20 related 1 (Drosophila)
51547SIRT7sirtuin 7
51548SIRT6sirtuin 6
51701NLKnemo-like kinase
54623PAF1Paf1_ RNA polymerase II associated factor_ homolog (S. cerevisiae)
54822TRPM7Transient receptor potential cation channel_ subfamily M_ member 7
55589BMP2KBMP2 inducible kinase
55666NPLOC4nuclear protein localization 4 homolog (S. cerevisiae)
55869HDAC8histone deacetylase 8
57551TAOK1TAO kinase 1
59343SENP2SUMO1/sentrin/SMT3 specific peptidase 2
60559SPCS3signal peptidase complex subunit 3 homolog (S. cerevisiae)
64699TMPRSS3transmembrane protease_ serine 3
64714PDIA2protein disulfide isomerase family A_ member 2
79885HDAC11histone deacetylase 11
83933HDAC10histone deacetylase 10
84447SYVN1synovial apoptosis inhibitor 1_ synoviolin
84867PTPN5Protein tyrosine phosphatase_ non-receptor type 5 (striatum-enriched)
112398EGLN2egl nine homolog 2 (C. elegans)
114769CARD16caspase recruitment domain family_ member 16
115426UHRF2ubiquitin-like with PHD and ring finger domains 2_ E3 ubiquitin protein ligase
120329CASP12caspase 12 (gene/pseudogene)
131890GRK7G protein-coupled receptor kinase 7
150290DUSP18dual specificity phosphatase 18
284086NEK8NIMA (never in mitosis gene a)- related kinase 8
389840MAP3K15Mitogen-activated protein kinase kinase kinase 15