PFAM ID:GO:0043285
Term :biopolymer catabolic process
Entrez Gene IDs are linked to their corresponding NCBI GenBank entry.
Gene symbols are linked to the entry for the gene in the HD Research CrossRoads database.
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Entrez Gene IDApproved SymbolApproved Name
207AKT1v-akt murine thymoma viral oncogene homolog 1
331XIAPX-linked inhibitor of apoptosis
348APOEapolipoprotein E
581BAXBCL2-associated X protein
701BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)
726CAPN5calpain 5
823CAPN1calpain 1_ (mu/I) large subunit
824CAPN2calpain 2_ (m/II) large subunit
834CASP1caspase 1_ apoptosis-related cysteine peptidase (interleukin 1_ beta_ convertase)
835CASP2caspase 2_ apoptosis-related cysteine peptidase
836CASP3caspase 3_ apoptosis-related cysteine peptidase
839CASP6caspase 6_ apoptosis-related cysteine peptidase
840CASP7caspase 7_ apoptosis-related cysteine peptidase
841CASP8caspase 8_ apoptosis-related cysteine peptidase
842CASP9caspase 9_ apoptosis-related cysteine peptidase
891CCNB1cyclin B1
1508CTSBcathepsin B
1509CTSDcathepsin D
1514CTSL1cathepsin L1
1636ACEangiotensin I converting enzyme (peptidyl-dipeptidase A) 1
2071ERCC3excision repair cross-complementing rodent repair deficiency_ complementation group 3 (xeroderma pigmentosum group B complementing)
2073ERCC5excision repair cross-complementing rodent repair deficiency_ complementation group 5
2237FEN1flap structure-specific endonuclease 1
2475MTORmechanistic target of rapamycin (serine/threonine kinase)
2903GRIN2Aglutamate receptor_ ionotropic_ N-methyl D-aspartate 2A
2935GSPT1G1 to S phase transition 1
3066HDAC2histone deacetylase 2
3093UBE2Kubiquitin-conjugating enzyme E2K (UBC1 homolog_ yeast)
3646EIF3Eeukaryotic translation initiation factor 3_ subunit E
3818KLKB1kallikrein B_ plasma (Fletcher factor) 1
4319MMP10matrix metallopeptidase 10 (stromelysin 2)
4323MMP14matrix metallopeptidase 14 (membrane-inserted)
4905NSFN-ethylmaleimide-sensitive factor
4968OGG18-oxoguanine DNA glycosylase
5071PARK2parkinson protein 2_ E3 ubiquitin protein ligase (parkin)
5655KLK10kallikrein-related peptidase 10
5663PSEN1presenilin 1
5664PSEN2presenilin 2 (Alzheimer disease 4)
5682PSMA1proteasome (prosome_ macropain) subunit_ alpha type_ 1
5686PSMA5proteasome (prosome_ macropain) subunit_ alpha type_ 5
5688PSMA7proteasome (prosome_ macropain) subunit_ alpha type_ 7
5690PSMB2proteasome (prosome_ macropain) subunit_ beta type_ 2
5691PSMB3proteasome (prosome_ macropain) subunit_ beta type_ 3
5693PSMB5proteasome (prosome_ macropain) subunit_ beta type_ 5
5694PSMB6proteasome (prosome_ macropain) subunit_ beta type_ 6
5695PSMB7proteasome (prosome_ macropain) subunit_ beta type_ 7
5701PSMC2proteasome (prosome_ macropain) 26S subunit_ ATPase_ 2
5702PSMC3proteasome (prosome_ macropain) 26S subunit_ ATPase_ 3
5705PSMC5proteasome (prosome_ macropain) 26S subunit_ ATPase_ 5
5706PSMC6proteasome (prosome_ macropain) 26S subunit_ ATPase_ 6
5708PSMD2proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 2
5709PSMD3proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 3
5710PSMD4proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 4
5713PSMD7proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 7
5714PSMD8proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 8
5717PSMD11proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 11
5903RANBP2RAN binding protein 2
5976UPF1UPF1 regulator of nonsense transcripts homolog (yeast)
6477SIAH1seven in absentia homolog 1 (Drosophila)
6500SKP1S-phase kinase-associated protein 1
6612SUMO3SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
6647SOD1superoxide dismutase 1_ soluble
7078TIMP3TIMP metallopeptidase inhibitor 3
7251TSG101tumor susceptibility gene 101
7314UBBubiquitin B
7317UBA1ubiquitin-like modifier activating enzyme 1
7319UBE2Aubiquitin-conjugating enzyme E2A (RAD6 homolog)
7322UBE2D2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog_ yeast)
7323UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog_ yeast)
7328UBE2Hubiquitin-conjugating enzyme E2H (UBC8 homolog_ yeast)
7329UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog_ yeast)
7334UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog_ yeast)
7336UBE2V2ubiquitin-conjugating enzyme E2 variant 2
7337UBE3Aubiquitin protein ligase E3A
7341SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
7345UCHL1Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
7347UCHL3ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
7353UFD1Lubiquitin fusion degradation 1 like (yeast)
7415VCPvalosin-containing protein
8239USP9Xubiquitin specific peptidase 9_ X-linked
8453CUL2cullin 2
8454CUL1cullin 1
8510MMP23Bmatrix metallopeptidase 23B
8878SQSTM1sequestosome 1
8945BTRCbeta-transducin repeat containing
9184BUB3budding uninhibited by benzimidazoles 3 homolog (yeast)
9730VPRBPVpr (HIV-1) binding protein
9924PAN2PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
10054UBA2ubiquitin-like modifier activating enzyme 2
10055SAE1SUMO1 activating enzyme subunit 1
10197PSME3proteasome (prosome_ macropain) activator subunit 3 (PA28 gamma; Ki)
10213PSMD14proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 14
10273STUB1STIP1 homology and U-box containing protein 1_ E3 ubiquitin protein ligase
10533ATG7ATG7 autophagy related 7 homolog (S. cerevisiae)
10939AFG3L2AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
11012KLK11kallikrein-related peptidase 11
23049SMG1SMG1 homolog_ phosphatidylinositol 3-kinase-related kinase (C. elegans)
23077MYCBP2MYC binding protein 2
23381SMG5Smg-5 homolog_ nonsense mediated mRNA decay factor (C. elegans)
25825BACE2beta-site APP-cleaving enzyme 2
26019UPF2UPF2 regulator of nonsense transcripts homolog (yeast)
26260FBXO25F-box protein 25
27429HTRA2HtrA serine peptidase 2
28972SPCS1signal peptidase complex subunit 1 homolog (S. cerevisiae)
51343FZR1fizzy/cell division cycle 20 related 1 (Drosophila)
55666NPLOC4nuclear protein localization 4 homolog (S. cerevisiae)
59343SENP2SUMO1/sentrin/SMT3 specific peptidase 2
64699TMPRSS3transmembrane protease_ serine 3
84447SYVN1synovial apoptosis inhibitor 1_ synoviolin
112398EGLN2egl nine homolog 2 (C. elegans)
114769CARD16caspase recruitment domain family_ member 16
115426UHRF2ubiquitin-like with PHD and ring finger domains 2_ E3 ubiquitin protein ligase
120329CASP12caspase 12 (gene/pseudogene)