PFAM ID:GO:0065009
Term :regulation of molecular function
Entrez Gene IDs are linked to their corresponding NCBI GenBank entry.
Gene symbols are linked to the entry for the gene in the HD Research CrossRoads database.
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Entrez Gene IDApproved SymbolApproved Name
116ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary)
117ADCYAP1R1adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
118ADD1adducin 1 (alpha)
135ADORA2Aadenosine A2a receptor
136ADORA2Badenosine A2b receptor
207AKT1v-akt murine thymoma viral oncogene homolog 1
317APAF1apoptotic peptidase activating factor 1
348APOEapolipoprotein E
367ARandrogen receptor
538ATP7AATPase_ Cu++ transporting_ alpha polypeptide
581BAXBCL2-associated X protein
596BCL2B-cell CLL/lymphoma 2
701BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)
836CASP3caspase 3_ apoptosis-related cysteine peptidase
842CASP9caspase 9_ apoptosis-related cysteine peptidase
847CATcatalase
857CAV1caveolin 1_ caveolae protein_ 22kDa
859CAV3caveolin 3
875CBScystathionine-beta-synthase
891CCNB1cyclin B1
1020CDK5cyclin-dependent kinase 5
1128CHRM1cholinergic receptor_ muscarinic 1
1129CHRM2cholinergic receptor_ muscarinic 2
1133CHRM5cholinergic receptor_ muscarinic 5
1241LTB4Rleukotriene B4 receptor
1508CTSBcathepsin B
1812DRD1dopamine receptor D1
1813DRD2dopamine receptor D2
1814DRD3dopamine receptor D3
1815DRD4dopamine receptor D4
1816DRD5dopamine receptor D5
1827RCAN1regulator of calcineurin 1
1950EGFepidermal growth factor
2247FGF2fibroblast growth factor 2 (basic)
2357FPR1formyl peptide receptor 1
2550GABBR1gamma-aminobutyric acid (GABA) B receptor_ 1
2668GDNFglial cell derived neurotrophic factor
2740GLP1Rglucagon-like peptide 1 receptor
2778GNASGNAS complex locus
2782GNB1guanine nucleotide binding protein (G protein)_ beta polypeptide 1
2810SFNstratifin
2847MCHR1melanin-concentrating hormone receptor 1
2912GRM2glutamate receptor_ metabotropic 2
2913GRM3glutamate receptor_ metabotropic 3
2914GRM4glutamate receptor_ metabotropic 4
2915GRM5glutamate receptor_ metabotropic 5
2917GRM7glutamate receptor_ metabotropic 7
2918GRM8glutamate receptor_ metabotropic 8
2931GSK3Aglycogen synthase kinase 3 alpha
2956MSH6mutS homolog 6 (E. coli)
3062HCRTR2hypocretin (orexin) receptor 2
3066HDAC2histone deacetylase 2
3084NRG1neuregulin 1
3091HIF1Ahypoxia inducible factor 1_ alpha subunit (basic helix-loop-helix transcription factor)
3092HIP1huntingtin interacting protein 1
3162HMOX1heme oxygenase (decycling) 1
3309HSPA5heat shock 70kDa protein 5 (glucose-regulated protein_ 78kDa)
3358HTR2C5-hydroxytryptamine (serotonin) receptor 2C
3551IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells_ kinase beta
3643INSRinsulin receptor
3654IRAK1interleukin-1 receptor-associated kinase 1
3717JAK2Janus kinase 2
4214MAP3K1mitogen-activated protein kinase kinase kinase 1
4217MAP3K5mitogen-activated protein kinase kinase kinase 5
4255MGMTO-6-methylguanine-DNA methyltransferase
4293MAP3K9mitogen-activated protein kinase kinase kinase 9
4294MAP3K10mitogen-activated protein kinase kinase kinase 10
4296MAP3K11mitogen-activated protein kinase kinase kinase 11
4436MSH2mutS homolog 2_ colon cancer_ nonpolyposis type 1 (E. coli)
4437MSH3mutS homolog 3 (E. coli)
4790NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
4914NTRK1neurotrophic tyrosine kinase_ receptor_ type 1
4985OPRD1opioid receptor_ delta 1
4986OPRK1opioid receptor_ kappa 1
4987OPRL1opiate receptor-like 1
5023P2RX1purinergic receptor P2X_ ligand-gated ion channel_ 1
5028P2RY1purinergic receptor P2Y_ G-protein coupled_ 1
5029P2RY2purinergic receptor P2Y_ G-protein coupled_ 2
5030P2RY4pyrimidinergic receptor P2Y_ G-protein coupled_ 4
5031P2RY6pyrimidinergic receptor P2Y_ G-protein coupled_ 6
5032P2RY11purinergic receptor P2Y_ G-protein coupled_ 11
5058PAK1p21 protein (Cdc42/Rac)-activated kinase 1
5062pak2p21 protein (Cdc42/Rac)-activated kinase 2
5291PIK3CBphosphoinositide-3-kinase_ catalytic_ beta polypeptide
5300PIN1peptidylprolyl cis/trans isomerase_ NIMA-interacting 1
5347PLK1polo-like kinase 1
5578PRKCAprotein kinase C_ alpha
5580PRKCDprotein kinase C_ delta
5604MAP2K1mitogen-activated protein kinase kinase 1
5606MAP2K3mitogen-activated protein kinase kinase 3
5608MAP2K6mitogen-activated protein kinase kinase 6
5663PSEN1presenilin 1
5664PSEN2presenilin 2 (Alzheimer disease 4)
5682PSMA1proteasome (prosome_ macropain) subunit_ alpha type_ 1
5686PSMA5proteasome (prosome_ macropain) subunit_ alpha type_ 5
5688PSMA7proteasome (prosome_ macropain) subunit_ alpha type_ 7
5690PSMB2proteasome (prosome_ macropain) subunit_ beta type_ 2
5691PSMB3proteasome (prosome_ macropain) subunit_ beta type_ 3
5693PSMB5proteasome (prosome_ macropain) subunit_ beta type_ 5
5694PSMB6proteasome (prosome_ macropain) subunit_ beta type_ 6
5695PSMB7proteasome (prosome_ macropain) subunit_ beta type_ 7
5701PSMC2proteasome (prosome_ macropain) 26S subunit_ ATPase_ 2
5702PSMC3proteasome (prosome_ macropain) 26S subunit_ ATPase_ 3
5705PSMC5proteasome (prosome_ macropain) 26S subunit_ ATPase_ 5
5706PSMC6proteasome (prosome_ macropain) 26S subunit_ ATPase_ 6
5708PSMD2proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 2
5709PSMD3proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 3
5710PSMD4proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 4
5713PSMD7proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 7
5714PSMD8proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 8
5717PSMD11proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 11
5728PTENphosphatase and tensin homolog
6188RPS3ribosomal protein S3
6500SKP1S-phase kinase-associated protein 1
6597SMARCA4SWI/SNF related_ matrix associated_ actin dependent regulator of chromatin_ subfamily a_ member 4
6647SOD1superoxide dismutase 1_ soluble
6786STIM1stromal interaction molecule 1
7052TGM2transglutaminase 2 (C polypeptide_ protein-glutamine-gamma-glutamyltransferase)
7157TP53tumor protein p53
7248TSC1tuberous sclerosis 1
7249TSC2tuberous sclerosis 2
7314UBBubiquitin B
7334UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog_ yeast)
7341SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
7376NR1H2nuclear receptor subfamily 1_ group H_ member 2
7415VCPvalosin-containing protein
8454CUL1cullin 1
8721EDF1endothelial differentiation-related factor 1
8767RIPK2receptor-interacting serine-threonine kinase 2
8797TNFRSF10Atumor necrosis factor receptor superfamily_ member 10a
8851CDK5R1cyclin-dependent kinase 5_ regulatory subunit 1 (p35)
8941CDK5R2cyclin-dependent kinase 5_ regulatory subunit 2 (p39)
8945BTRCbeta-transducin repeat containing
9184BUB3budding uninhibited by benzimidazoles 3 homolog (yeast)
9241NOGnoggin
10049DNAJB6DnaJ (Hsp40) homolog_ subfamily B_ member 6
10062NR1H3nuclear receptor subfamily 1_ group H_ member 3
10197PSME3proteasome (prosome_ macropain) activator subunit 3 (PA28 gamma; Ki)
10213PSMD14proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 14
10487CAP1CAP_ adenylate cyclase-associated protein 1 (yeast)
23411SIRT1sirtuin 1
23560GTPBP4GTP binding protein 4
23636NUP62nucleoporin 62kDa
26173INTS1integrator complex subunit 1
51196PLCE1Phospholipase C_ epsilon 1
51343FZR1fizzy/cell division cycle 20 related 1 (Drosophila)
54583EGLN1egl nine homolog 1 (C. elegans)
55081IFT57intraflagellar transport 57 homolog (Chlamydomonas)
55803ADAP2ArfGAP with dual PH domains 2
56848SPHK2sphingosine kinase 2