PFAM ID:GO:0032991
Term :macromolecular complex
Entrez Gene IDs are linked to their corresponding NCBI GenBank entry.
Gene symbols are linked to the entry for the gene in the HD Research CrossRoads database.
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Entrez Gene IDApproved SymbolApproved Name
60ACTBactin_ beta
118ADD1adducin 1 (alpha)
160AP2A1Adaptor-related protein complex 2_ alpha 1 subunit
161AP2A2adaptor-related protein complex 2_ alpha 2 subunit
162AP1B1adaptor-related protein complex 1_ beta 1 subunit
164AP1G1adaptor-related protein complex 1_ gamma 1 subunit
348APOEapolipoprotein E
372ARCN1archain 1
476ATP1A1ATPase_ Na+/K+ transporting_ alpha 1 polypeptide
498ATP5A1ATP synthase_ H+ transporting_ mitochondrial F1 complex_ alpha subunit 1_ cardiac muscle
506ATP5BATP synthase_ H+ transporting_ mitochondrial F1 complex_ beta polypeptide
513ATP5DATP synthase_ H+ transporting_ mitochondrial F1 complex_ delta subunit
515ATP5F1ATP synthase_ H+ transporting_ mitochondrial Fo complex_ subunit B1
523ATP6V1AATPase_ H+ transporting_ lysosomal 70kDa_ V1 subunit A
525ATP6V1B1ATPase_ H+ transporting_ lysosomal 56/58kDa_ V1 subunit B1
526ATP6V1B2ATPase_ H+ transporting_ lysosomal 56/58kDa_ V1 subunit B2
529ATP6V1E1ATPase_ H+ transporting_ lysosomal 31kDa_ V1 subunit E1
535ATP6V0A1ATPase_ H+ transporting_ lysosomal V0 subunit a1
596BCL2B-cell CLL/lymphoma 2
701BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)
774CACNA1Bcalcium channel_ voltage-dependent_ N type_ alpha 1B subunit
776CACNA1Dcalcium channel_ voltage-dependent_ L type_ alpha 1D subunit
781CACNA2D1calcium channel_ voltage-dependent_ alpha 2/delta subunit 1
841CASP8caspase 8_ apoptosis-related cysteine peptidase
859CAV3caveolin 3
908CCT6Achaperonin containing TCP1_ subunit 6A (zeta 1)
988CDC5LCDC5 cell division cycle 5-like (S. pombe)
1173AP2M1adaptor-related protein complex 2_ mu 1 subunit
1211CLTAclathrin_ light chain A
1213CLTCclathrin_ heavy chain (Hc)
1387CREBBPCREB binding protein
1434CSE1LCSE1 chromosome segregation 1-like (yeast)
1457CSNK2A1casein kinase 2_ alpha 1 polypeptide
1460CSNK2Bcasein kinase 2_ beta polypeptide
1499CTNNB1catenin (cadherin-associated protein)_ beta 1_ 88kDa
1639DCTN1dynactin 1
1659DHX8DEAH (Asp-Glu-Ala-His) box polypeptide 8
1737DLATdihydrolipoamide S-acetyltransferase
1742DLG4discs_ large homolog 4 (Drosophila)
1743DLSTdihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
1778DYNC1H1Dynein_ cytoplasmic 1_ heavy chain 1
1781DYNC1I2dynein_ cytoplasmic 1_ intermediate chain 2
1917EEF1A2eukaryotic translation elongation factor 1 alpha 2
1938EEF2eukaryotic translation elongation factor 2
2071ERCC3excision repair cross-complementing rodent repair deficiency_ complementation group 3 (xeroderma pigmentosum group B complementing)
2073ERCC5excision repair cross-complementing rodent repair deficiency_ complementation group 5
2243FGAfibrinogen alpha chain
2495FTH1ferritin_ heavy polypeptide 1
2512FTLferritin_ light polypeptide
2547XRCC6X-ray repair complementing defective repair in Chinese hamster cells 6
2554GABRA1gamma-aminobutyric acid (GABA) A receptor_ alpha 1
2566GABRG2gamma-aminobutyric acid (GABA) A receptor_ gamma 2
2648KAT2AK(lysine) acetyltransferase 2A
2770GNAI1guanine nucleotide binding protein (G protein)_ alpha inhibiting activity polypeptide 1
2778GNASGNAS complex locus
2782GNB1guanine nucleotide binding protein (G protein)_ beta polypeptide 1
2819GPD1glycerol-3-phosphate dehydrogenase 1 (soluble)
2890GRIA1glutamate receptor_ ionotropic_ AMPA 1
2891GRIA2glutamate receptor_ ionotropic_ AMPA 2
2902GRIN1glutamate receptor_ ionotropic_ N-methyl D-aspartate 1
2903GRIN2Aglutamate receptor_ ionotropic_ N-methyl D-aspartate 2A
2904GRIN2Bglutamate receptor_ ionotropic_ N-methyl D-aspartate 2B
2932GSK3Bglycogen synthase kinase 3 beta
2956MSH6mutS homolog 6 (E. coli)
3065HDAC1histone deacetylase 1
3066HDAC2histone deacetylase 2
3091HIF1Ahypoxia inducible factor 1_ alpha subunit (basic helix-loop-helix transcription factor)
3178HNRNPA1heterogeneous nuclear ribonucleoprotein A1
3309HSPA5heat shock 70kDa protein 5 (glucose-regulated protein_ 78kDa)
3479IGF1insulin-like growth factor 1 (somatomedin C)
3570IL6Rinterleukin 6 receptor
3572IL6STinterleukin 6 signal transducer (gp130_ oncostatin M receptor)
3643INSRinsulin receptor
3646EIF3Eeukaryotic translation initiation factor 3_ subunit E
3654IRAK1interleukin-1 receptor-associated kinase 1
3674ITGA2Bintegrin_ alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex_ antigen CD41)
3725JUNjun proto-oncogene
3736KCNA1potassium voltage-gated channel_ shaker-related subfamily_ member 1 (episodic ataxia with myokymia)
3767KCNJ11potassium inwardly-rectifying channel_ subfamily J_ member 11
3799KIF5Bkinesin family member 5B
3831KLC1kinesin light chain 1
3832KIF11kinesin family member 11
3843IPO5importin 5
3921RPSAribosomal protein SA
4023LPLlipoprotein lipase
4436MSH2mutS homolog 2_ colon cancer_ nonpolyposis type 1 (E. coli)
4437MSH3mutS homolog 3 (E. coli)
4542MYO1Fmyosin IF
4628MYH10myosin_ heavy chain 10_ non-muscle
4716NDUFB10NADH dehydrogenase (ubiquinone) 1 beta subcomplex_ 10_ 22kDa
4723NDUFV1NADH dehydrogenase (ubiquinone) flavoprotein 1_ 51kDa
4790NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
4809NHP2L1NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
4928NUP98nucleoporin 98kDa
5213PFKMphosphofructokinase_ muscle
5286PIK3C2Aphosphoinositide-3-kinase_ class 2_ alpha polypeptide
5289PIK3C3phosphoinositide-3-kinase_ class 3
5290PIK3CAphosphoinositide-3-kinase_ catalytic_ alpha polypeptide
5291PIK3CBphosphoinositide-3-kinase_ catalytic_ beta polypeptide
5295PIK3R1phosphoinositide-3-kinase_ regulatory subunit 1 (alpha)
5296PIK3R2phosphoinositide-3-kinase_ regulatory subunit 2 (beta)
5356PLRG1pleiotropic regulator 1 (PRL1 homolog_ Arabidopsis)
5430POLR2Apolymerase (RNA) II (DNA directed) polypeptide A_ 220kDa
5431POLR2BPolymerase (RNA) II (DNA directed) polypeptide B_ 140kDa
5495PPM1Bprotein phosphatase_ Mg2+/Mn2+ dependent_ 1B
5499PPP1CAprotein phosphatase 1_ catalytic subunit_ alpha isozyme
5530PPP3CAprotein phosphatase 3_ catalytic subunit_ alpha isozyme
5534PPP3R1protein phosphatase 3_ regulatory subunit B_ alpha
5557PRIM1primase_ DNA_ polypeptide 1 (49kDa)
5566PRKACAprotein kinase_ cAMP-dependent_ catalytic_ alpha
5567PRKACBprotein kinase_ cAMP-dependent_ catalytic_ beta
5573PRKAR1Aprotein kinase_ cAMP-dependent_ regulatory_ type I_ alpha (tissue specific extinguisher 1)
5575PRKAR1Bprotein kinase_ cAMP-dependent_ regulatory_ type I_ beta
5576PRKAR2Aprotein kinase_ cAMP-dependent_ regulatory_ type II_ alpha
5577PRKAR2Bprotein kinase_ cAMP-dependent_ regulatory_ type II_ beta
5663PSEN1presenilin 1
5682PSMA1proteasome (prosome_ macropain) subunit_ alpha type_ 1
5686PSMA5proteasome (prosome_ macropain) subunit_ alpha type_ 5
5688PSMA7proteasome (prosome_ macropain) subunit_ alpha type_ 7
5690PSMB2proteasome (prosome_ macropain) subunit_ beta type_ 2
5691PSMB3proteasome (prosome_ macropain) subunit_ beta type_ 3
5693PSMB5proteasome (prosome_ macropain) subunit_ beta type_ 5
5694PSMB6proteasome (prosome_ macropain) subunit_ beta type_ 6
5695PSMB7proteasome (prosome_ macropain) subunit_ beta type_ 7
5701PSMC2proteasome (prosome_ macropain) 26S subunit_ ATPase_ 2
5702PSMC3proteasome (prosome_ macropain) 26S subunit_ ATPase_ 3
5705PSMC5proteasome (prosome_ macropain) 26S subunit_ ATPase_ 5
5706PSMC6proteasome (prosome_ macropain) 26S subunit_ ATPase_ 6
5708PSMD2proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 2
5709PSMD3proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 3
5710PSMD4proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 4
5713PSMD7proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 7
5714PSMD8proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 8
5717PSMD11proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 11
5743PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
5901RANRAN_ member RAS oncogene family
5903RANBP2RAN binding protein 2
5976UPF1UPF1 regulator of nonsense transcripts homolog (yeast)
6009RHEBRas homolog enriched in brain
6125RPL5ribosomal protein L5
6128RPL6ribosomal protein L6
6129RPL7ribosomal protein L7
6130RPL7Aribosomal protein L7a
6132RPL8ribosomal protein L8
6137RPL13Ribosomal protein L13
6138RPL15ribosomal protein L15
6139RPL17ribosomal protein L17
6141RPL18ribosomal protein L18
6142RPL18Aribosomal protein L18a
6143RPL19ribosomal protein L19
6146RPL22ribosomal protein L22
6152RPL24ribosomal protein L24
6154RPL26ribosomal protein L26
6160RPL31ribosomal protein L31
6170RPL39ribosomal protein L39
6175RPLP0ribosomal protein_ large_ P0
6187RPS2ribosomal protein S2
6188RPS3ribosomal protein S3
6189RPS3Aribosomal protein S3A
6193RPS5ribosomal protein S5
6204RPS10ribosomal protein S10
6206RPS12ribosomal protein S12
6209RPS15Ribosomal protein S15
6217RPS16ribosomal protein S16
6222RPS18ribosomal protein S18
6227RPS21ribosomal protein S21
6249CLIP1CAP-GLY domain containing linker protein 1
6311ATXN2ataxin 2
6323SCN1Asodium channel_ voltage-gated_ type I_ alpha subunit
6330SCN4Bsodium channel_ voltage-gated_ type IV_ beta
6389SDHAsuccinate dehydrogenase complex_ subunit A_ flavoprotein (Fp)
6500SKP1S-phase kinase-associated protein 1
6597SMARCA4SWI/SNF related_ matrix associated_ actin dependent regulator of chromatin_ subfamily a_ member 4
6601SMARCC2SWI/SNF related_ matrix associated_ actin dependent regulator of chromatin_ subfamily c_ member 2
6612SUMO3SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
6616SNAP25Synaptosomal-associated protein_ 25kDa
6628SNRPBsmall nuclear ribonucleoprotein polypeptides B and B1
6632SNRPD1small nuclear ribonucleoprotein D1 polypeptide 16kDa
6633SNRPD2small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
6634SNRPD3small nuclear ribonucleoprotein D3 polypeptide 18kDa
6636SNRPFsmall nuclear ribonucleoprotein polypeptide F
6637SNRPGsmall nuclear ribonucleoprotein polypeptide G
6647SOD1superoxide dismutase 1_ soluble
6653SORL1sortilin-related receptor_ L(DLR class) A repeats-containing
6874TAF4TAF4 RNA polymerase II_ TATA box binding protein (TBP)-associated factor_ 135kDa
6875TAF4BTAF4b RNA polymerase II_ TATA box binding protein (TBP)-associated factor_ 105kDa
7029TFDP2transcription factor Dp-2 (E2F dimerization partner 2)
7099TLR4toll-like receptor 4
7138TNNT1troponin T type 1 (skeletal_ slow)
7157TP53tumor protein p53
7220TRPC1transient receptor potential cation channel_ subfamily C_ member 1
7248TSC1tuberous sclerosis 1
7249TSC2tuberous sclerosis 2
7307U2AF1U2 small nuclear RNA auxiliary factor 1
7334UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog_ yeast)
7336UBE2V2ubiquitin-conjugating enzyme E2 variant 2
7337UBE3Aubiquitin protein ligase E3A
7341SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
7846TUBA1Atubulin_ alpha 1a
7919BAT1DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
7942TFEBtranscription factor EB
8295TRRAPtransformation/transcription domain-associated protein
8453CUL2cullin 2
8454CUL1cullin 1
8517IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells_ kinase gamma
8539API5apoptosis inhibitor 5
8568RRP1ribosomal RNA processing 1 homolog (S. cerevisiae)
8661EIF3Aeukaryotic translation initiation factor 3_ subunit A
8662EIF3Beukaryotic translation initiation factor 3_ subunit B
8668EIF3Ieukaryotic translation initiation factor 3_ subunit I
8678BECN1Beclin 1_ autophagy related
8721EDF1endothelial differentiation-related factor 1
8841HDAC3histone deacetylase 3
8851CDK5R1cyclin-dependent kinase 5_ regulatory subunit 1 (p35)
8894EIF2S2eukaryotic translation initiation factor 2_ subunit 2 beta_ 38kDa
8905AP1S2adaptor-related protein complex 1_ sigma 2 subunit
8941CDK5R2cyclin-dependent kinase 5_ regulatory subunit 2 (p39)
9022CLIC3chloride intracellular channel 3
9045RPL14ribosomal protein L14
9126SMC3Structural maintenance of chromosomes 3
9184BUB3budding uninhibited by benzimidazoles 3 homolog (yeast)
9343EFTUD2elongation factor Tu GTP binding domain containing 2
9349RPL23ribosomal protein L23
9439MED23mediator complex subunit 23
9631NUP155nucleoporin 155kDa
9734HDAC9histone deacetylase 9
9759HDAC4histone deacetylase 4
9892SNAP91synaptosomal-associated protein_ 91kDa homolog (mouse)
9972NUP153nucleoporin 153kDa
10013HDAC6histone deacetylase 6
10014HDAC5histone deacetylase 5
10053AP1M2adaptor-related protein complex 1_ mu 2 subunit
10109ARPC2actin related protein 2/3 complex_ subunit 2_ 34kDa
10197PSME3proteasome (prosome_ macropain) activator subunit 3 (PA28 gamma; Ki)
10204NUTF2nuclear transport factor 2
10213PSMD14proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 14
10262SF3B4splicing factor 3b_ subunit 4_ 49kDa
10273STUB1STIP1 homology and U-box containing protein 1_ E3 ubiquitin protein ligase
10411RAPGEF3Rap guanine nucleotide exchange factor (GEF) 3
10476ATP5HATP synthase_ H+ transporting_ mitochondrial Fo complex_ subunit d
10484SEC23ASec23 homolog A (S. cerevisiae)
10558SPTLC1serine palmitoyltransferase_ long chain base subunit 1
10569SLU7SLU7 splicing factor homolog (S. cerevisiae)
10575CCT4chaperonin containing TCP1_ subunit 4 (delta)
10576CCT2chaperonin containing TCP1_ subunit 2 (beta)
10594PRPF8PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
10891PPARGC1Aperoxisome proliferator-activated receptor gamma_ coactivator 1 alpha
10946SF3A3splicing factor 3a_ subunit 3_ 60kDa
10992SF3B2splicing factor 3b_ subunit 2_ 145kDa
11224RPL35ribosomal protein L35
22873DZIP1DAZ interacting protein 1
22933SIRT2sirtuin 2
22938SNW1SNW domain containing 1
22948CCT5chaperonin containing TCP1_ subunit 5 (epsilon)
23020SNRNP200small nuclear ribonucleoprotein 200kDa (U5)
23077MYCBP2MYC binding protein 2
23279NUP160nucleoporin 160kDa
23450SF3B3splicing factor 3b_ subunit 3_ 130kDa
23451SF3B1splicing factor 3b_ subunit 1_ 155kDa
23481PES1pescadillo homolog 1_ containing BRCT domain (zebrafish)
23517SKIV2L2Superkiller viralicidic activity 2-like 2 (S. cerevisiae)
23636NUP62nucleoporin 62kDa
25896INTS7integrator complex subunit 7
25942SIN3ASIN3 homolog A_ transcription regulator (yeast)
26100WIPI2WD repeat domain_ phosphoinositide interacting 2
26121PRPF31PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae)
26260FBXO25F-box protein 25
27161EIF2C2Eukaryotic translation initiation factor 2C_ 2
27183VPS4Avacuolar protein sorting 4 homolog A (S. cerevisiae)
27339PRPF19PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
28972SPCS1signal peptidase complex subunit 1 homolog (S. cerevisiae)
29979UBQLN1ubiquilin 1
51176LEF1lymphoid enhancer-binding factor 1
51340CRNKL1crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
51343FZR1fizzy/cell division cycle 20 related 1 (Drosophila)
51606ATP6V1HATPase_ H+ transporting_ lysosomal 50/57kDa_ V1 subunit H
51616TAF9BTAF9B RNA polymerase II_ TATA box binding protein (TBP)-associated factor_ 31kDa
54039PCBP3poly(rC) binding protein 3
54623PAF1Paf1_ RNA polymerase II associated factor_ homolog (S. cerevisiae)
55656INTS8integrator complex subunit 8
55756INTS9integrator complex subunit 9
55869HDAC8histone deacetylase 8
56949XAB2XPA binding protein 2
56993TOMM22translocase of outer mitochondrial membrane 22 homolog (yeast)
57122NUP107nucleoporin 107kDa
57461ISY1ISY1 splicing factor homolog (S. cerevisiae)
57508INTS2integrator complex subunit 2
58509C19orf29chromosome 19 open reading frame 29
59343SENP2SUMO1/sentrin/SMT3 specific peptidase 2
60559SPCS3signal peptidase complex subunit 3 homolog (S. cerevisiae)
79885HDAC11histone deacetylase 11
80789INTS5integrator complex subunit 5
83657DYNLRB2dynein_ light chain_ roadblock-type 2
83933HDAC10histone deacetylase 10
92105INTS4integrator complex subunit 4
116443GRIN3Aglutamate receptor_ ionotropic_ N-methyl-D-aspartate 3A
116444GRIN3Bglutamate receptor_ ionotropic_ N-methyl-D-aspartate 3B
140890SFRS12Splicing factor_ arginine/serine-rich 12
192683SCAMP5secretory carrier membrane protein 5
203068TUBBtubulin_ beta
266743NPAS4neuronal PAS domain protein 4