PFAM ID:GO:0016787
Term :hydrolase activity
Entrez Gene IDs are linked to their corresponding NCBI GenBank entry.
Gene symbols are linked to the entry for the gene in the HD Research CrossRoads database.
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Entrez Gene IDApproved SymbolApproved Name
43ACHEacetylcholinesterase
191AHCYadenosylhomocysteinase
249ALPLalkaline phosphatase_ liver/bone/kidney
378ARF4ADP-ribosylation factor 4
387RHOAras homolog gene family_ member A
476ATP1A1ATPase_ Na+/K+ transporting_ alpha 1 polypeptide
498ATP5A1ATP synthase_ H+ transporting_ mitochondrial F1 complex_ alpha subunit 1_ cardiac muscle
506ATP5BATP synthase_ H+ transporting_ mitochondrial F1 complex_ beta polypeptide
513ATP5DATP synthase_ H+ transporting_ mitochondrial F1 complex_ delta subunit
515ATP5F1ATP synthase_ H+ transporting_ mitochondrial Fo complex_ subunit B1
523ATP6V1AATPase_ H+ transporting_ lysosomal 70kDa_ V1 subunit A
525ATP6V1B1ATPase_ H+ transporting_ lysosomal 56/58kDa_ V1 subunit B1
526ATP6V1B2ATPase_ H+ transporting_ lysosomal 56/58kDa_ V1 subunit B2
529ATP6V1E1ATPase_ H+ transporting_ lysosomal 31kDa_ V1 subunit E1
538ATP7AATPase_ Cu++ transporting_ alpha polypeptide
726CAPN5calpain 5
747DAGLAdiacylglycerol lipase_ alpha
823CAPN1calpain 1_ (mu/I) large subunit
824CAPN2calpain 2_ (m/II) large subunit
834CASP1caspase 1_ apoptosis-related cysteine peptidase (interleukin 1_ beta_ convertase)
835CASP2caspase 2_ apoptosis-related cysteine peptidase
836CASP3caspase 3_ apoptosis-related cysteine peptidase
839CASP6caspase 6_ apoptosis-related cysteine peptidase
840CASP7caspase 7_ apoptosis-related cysteine peptidase
841CASP8caspase 8_ apoptosis-related cysteine peptidase
842CASP9caspase 9_ apoptosis-related cysteine peptidase
847CATcatalase
1128CHRM1cholinergic receptor_ muscarinic 1
1131CHRM3cholinergic receptor_ muscarinic 3
1133CHRM5cholinergic receptor_ muscarinic 5
1508CTSBcathepsin B
1509CTSDcathepsin D
1514CTSL1cathepsin L1
1636ACEangiotensin I converting enzyme (peptidyl-dipeptidase A) 1
1639DCTN1dynactin 1
1659DHX8DEAH (Asp-Glu-Ala-His) box polypeptide 8
1759DNM1dynamin 1
1778DYNC1H1Dynein_ cytoplasmic 1_ heavy chain 1
1781DYNC1I2dynein_ cytoplasmic 1_ intermediate chain 2
1785DNM2dynamin 2
1847DUSP5dual specificity phosphatase 5
1849DUSP7dual specificity phosphatase 7
1917EEF1A2eukaryotic translation elongation factor 1 alpha 2
1938EEF2eukaryotic translation elongation factor 2
1968EIF2S3eukaryotic translation initiation factor 2_ subunit 3 gamma_ 52kDa
1983EIF5eukaryotic translation initiation factor 5
2071ERCC3excision repair cross-complementing rodent repair deficiency_ complementation group 3 (xeroderma pigmentosum group B complementing)
2073ERCC5excision repair cross-complementing rodent repair deficiency_ complementation group 5
2166FAAHfatty acid amide hydrolase
2184FAHfumarylacetoacetate hydrolase (fumarylacetoacetase)
2237FEN1flap structure-specific endonuclease 1
2547XRCC6X-ray repair complementing defective repair in Chinese hamster cells 6
2770GNAI1guanine nucleotide binding protein (G protein)_ alpha inhibiting activity polypeptide 1
2778GNASGNAS complex locus
2782GNB1guanine nucleotide binding protein (G protein)_ beta polypeptide 1
2935GSPT1G1 to S phase transition 1
2956MSH6mutS homolog 6 (E. coli)
3065HDAC1histone deacetylase 1
3066HDAC2histone deacetylase 2
3162HMOX1heme oxygenase (decycling) 1
3312HSPA8heat shock 70kDa protein 8
3612IMPA1inositol(myo)-1(or 4)-monophosphatase 1
3799KIF5Bkinesin family member 5B
3818KLKB1kallikrein B_ plasma (Fletcher factor) 1
3831KLC1kinesin light chain 1
3832KIF11kinesin family member 11
4023LPLlipoprotein lipase
4319MMP10matrix metallopeptidase 10 (stromelysin 2)
4323MMP14matrix metallopeptidase 14 (membrane-inserted)
4436MSH2mutS homolog 2_ colon cancer_ nonpolyposis type 1 (E. coli)
4521NUDT1nudix (nucleoside diphosphate linked moiety X)-type motif 1
4542MYO1Fmyosin IF
4628MYH10myosin_ heavy chain 10_ non-muscle
4671NAIPNLR family_ apoptosis inhibitory protein
4905NSFN-ethylmaleimide-sensitive factor
4968OGG18-oxoguanine DNA glycosylase
5136PDE1Aphosphodiesterase 1A_ calmodulin-dependent
5138PDE2Aphosphodiesterase 2A_ cGMP-stimulated
5141PDE4Aphosphodiesterase 4A_ cAMP-specific
5142PDE4Bphosphodiesterase 4B_ cAMP-specific
5144PDE4Dphosphodiesterase 4D_ cAMP-specific
5190PEX6peroxisomal biogenesis factor 6
5495PPM1Bprotein phosphatase_ Mg2+/Mn2+ dependent_ 1B
5499PPP1CAprotein phosphatase 1_ catalytic subunit_ alpha isozyme
5509PPP1R3Dprotein phosphatase 1_ regulatory (inhibitor) subunit 3D
5530PPP3CAprotein phosphatase 3_ catalytic subunit_ alpha isozyme
5534PPP3R1protein phosphatase 3_ regulatory subunit B_ alpha
5604MAP2K1mitogen-activated protein kinase kinase 1
5655KLK10kallikrein-related peptidase 10
5663PSEN1presenilin 1
5664PSEN2presenilin 2 (Alzheimer disease 4)
5682PSMA1proteasome (prosome_ macropain) subunit_ alpha type_ 1
5686PSMA5proteasome (prosome_ macropain) subunit_ alpha type_ 5
5688PSMA7proteasome (prosome_ macropain) subunit_ alpha type_ 7
5690PSMB2proteasome (prosome_ macropain) subunit_ beta type_ 2
5691PSMB3proteasome (prosome_ macropain) subunit_ beta type_ 3
5693PSMB5proteasome (prosome_ macropain) subunit_ beta type_ 5
5694PSMB6proteasome (prosome_ macropain) subunit_ beta type_ 6
5695PSMB7proteasome (prosome_ macropain) subunit_ beta type_ 7
5701PSMC2proteasome (prosome_ macropain) 26S subunit_ ATPase_ 2
5702PSMC3proteasome (prosome_ macropain) 26S subunit_ ATPase_ 3
5705PSMC5proteasome (prosome_ macropain) 26S subunit_ ATPase_ 5
5706PSMC6proteasome (prosome_ macropain) 26S subunit_ ATPase_ 6
5728PTENphosphatase and tensin homolog
5861RAB1ARAB1A_ member RAS oncogene family
5868RAB5ARAB5A_ member RAS oncogene family
5901RANRAN_ member RAS oncogene family
5976UPF1UPF1 regulator of nonsense transcripts homolog (yeast)
6009RHEBRas homolog enriched in brain
6188RPS3ribosomal protein S3
6597SMARCA4SWI/SNF related_ matrix associated_ actin dependent regulator of chromatin_ subfamily a_ member 4
7226TRPM2transient receptor potential cation channel_ subfamily M_ member 2
7345UCHL1Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
7347UCHL3ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
7353UFD1Lubiquitin fusion degradation 1 like (yeast)
7415VCPvalosin-containing protein
7846TUBA1Atubulin_ alpha 1a
7919BAT1DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
8239USP9Xubiquitin specific peptidase 9_ X-linked
8510MMP23Bmatrix metallopeptidase 23B
8622PDE8Bphosphodiesterase 8B
8654PDE5Aphosphodiesterase 5A_ cGMP-specific
8766RAB11ARAB11A_ member RAS oncogene family
8841HDAC3histone deacetylase 3
8867SYNJ1synaptojanin 1
8871SYNJ2synaptojanin 2
8898MTMR2myotubularin related protein 2
8942KYNUkynureninase (L-kynurenine hydrolase)
9126SMC3Structural maintenance of chromosomes 3
9230RAB11BRAB11B_ member RAS oncogene family
9343EFTUD2elongation factor Tu GTP binding domain containing 2
9429ABCG2ATP-binding cassette_ sub-family G (WHITE)_ member 2
9525VPS4Bvacuolar protein sorting 4 homolog B (S. cerevisiae)
9582APOBEC3Bapolipoprotein B mRNA editing enzyme_ catalytic polypeptide-like 3B
9734HDAC9histone deacetylase 9
9759HDAC4histone deacetylase 4
9924PAN2PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
9927MFN2mitofusin 2
10013HDAC6histone deacetylase 6
10014HDAC5histone deacetylase 5
10059DNM1Ldynamin 1-like
10212DDX39DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
10213PSMD14proteasome (prosome_ macropain) 26S subunit_ non-ATPase_ 14
10476ATP5HATP synthase_ H+ transporting_ mitochondrial Fo complex_ subunit d
10846PDE10Aphosphodiesterase 10A
10939AFG3L2AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
11012KLK11kallikrein-related peptidase 11
11343MGLLmonoglyceride lipase
22933SIRT2sirtuin 2
22985ACIN1apoptotic chromatin condensation inducer 1
23020SNRNP200small nuclear ribonucleoprotein 200kDa (U5)
23408SIRT5sirtuin 5
23409SIRT4sirtuin 4
23410SIRT3sirtuin 3
23411SIRT1sirtuin 1
23517SKIV2L2Superkiller viralicidic activity 2-like 2 (S. cerevisiae)
23551RASD2RASD family_ member 2
23560GTPBP4GTP binding protein 4
25788RAD54BRAD54 homolog B (S. cerevisiae)
25825BACE2beta-site APP-cleaving enzyme 2
27161EIF2C2Eukaryotic translation initiation factor 2C_ 2
27183VPS4Avacuolar protein sorting 4 homolog A (S. cerevisiae)
27429HTRA2HtrA serine peptidase 2
28972SPCS1signal peptidase complex subunit 1 homolog (S. cerevisiae)
51196PLCE1Phospholipase C_ epsilon 1
51547SIRT7sirtuin 7
51548SIRT6sirtuin 6
51606ATP6V1HATPase_ H+ transporting_ lysosomal 50/57kDa_ V1 subunit H
51692CPSF3cleavage and polyadenylation specific factor 3_ 73kDa
53981CPSF2cleavage and polyadenylation specific factor 2_ 100kDa
54973CPSF3Lcleavage and polyadenylation specific factor 3-like
55869HDAC8histone deacetylase 8
57406ABHD6abhydrolase domain containing 6
57455REXO1REX1_ RNA exonuclease 1 homolog (S. cerevisiae)
59084ENPP5ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
59343SENP2SUMO1/sentrin/SMT3 specific peptidase 2
60559SPCS3signal peptidase complex subunit 3 homolog (S. cerevisiae)
64699TMPRSS3transmembrane protease_ serine 3
79885HDAC11histone deacetylase 11
81570CLPBClpB caseinolytic peptidase B homolog (E. coli)
83657DYNLRB2dynein_ light chain_ roadblock-type 2
83933HDAC10histone deacetylase 10
84867PTPN5Protein tyrosine phosphatase_ non-receptor type 5 (striatum-enriched)
114769CARD16caspase recruitment domain family_ member 16
120329CASP12caspase 12 (gene/pseudogene)
150290DUSP18dual specificity phosphatase 18
162540IMP5intramembrane protease 5
203068TUBBtubulin_ beta
221955DAGLBdiacylglycerol lipase_ beta