PFAM enriched in HD-relevant genes

PFAM IDs are linked to the PFAM website (http://pfam.sanger.ac.uk/). The list of HD-relevant genes for each category can be found following the links provided in the Term column.

PFAMID P-Value FDR Odds Ratio Expected Count Count Total number Term
PF00069 2.22E-16 1.70E-13 3.81 19.88 63 362 Protein kinase domain
PF00850 1.30E-14 4.97E-12 In 0.60 11 11 Histone deacetylase domain
PF01094 1.83E-12 4.68E-10 14.88 2.03 17 37 Receptor family ligand binding region
PF00060 2.89E-10 4.43E-08 27.35 0.98 11 18 Ligand-gated ion channel
PF10613 2.89E-10 4.43E-08 27.35 0.98 11 18 Ligated ion channel L-glutamate- and glycine-binding site
PF02146 1.48E-09 1.89E-07 In 0.38 7 7 Sir2 family
PF00433 1.15E-07 1.25E-05 8.38 2.19 13 40 Protein kinase C terminal domain
PF00656 1.79E-07 1.54E-05 23.13 0.76 8 14 Caspase domain
PF00864 1.80E-07 1.54E-05 103.91 0.38 6 7 ATP P2X receptor
PF00209 2.45E-07 1.88E-05 15.62 1.04 9 19 Sodium:neurotransmitter symporter family
PF07562 3.66E-07 2.55E-05 19.82 0.82 8 15 Nine Cysteines Domain of family 3 GPCR
PF00006 4.95E-07 2.71E-05 In 0.27 5 5 ATP synthase alpha/beta family, nucleotide-binding domain
PF00306 4.95E-07 2.71E-05 In 0.27 5 5 ATP synthase alpha/beta chain, C terminal domain
PF02874 4.95E-07 2.71E-05 In 0.27 5 5 ATP synthase alpha/beta family, beta-barrel domain
PF00003 1.78E-06 9.09E-05 11.16 1.26 9 23 7 transmembrane sweet-taste receptor of 3 GCPR
PF00011 1.97E-06 9.43E-05 34.63 0.49 6 9 Hsp20/alpha crystallin family
PF00227 3.53E-06 0.000159 12.61 1.04 8 19 Proteasome A-type and B-type
PF00105 4.82E-06 0.000205 6.13 2.52 12 46 Zinc finger, C4 type (two domains)
PF00104 7.79E-06 0.000314 5.79 2.63 12 48 Ligand-binding domain of nuclear hormone receptor
PF00233 8.61E-06 0.000330 10.67 1.15 8 21 3'5'-cyclic nucleotide phosphodiesterase
PF00454 4.14E-05 0.001513 10.10 1.04 7 19 Phosphatidylinositol 3- and 4-kinase
PF00118 0.000134326 0.004367 10.38 0.87 6 16 TCP-1/cpn60 chaperonin family
PF00226 0.000192087 0.004911 4.69 2.58 10 47 DnaJ domain
PF00004 0.000230841 0.005711 4.56 2.63 10 48 ATPase family associated with various cellular activities (AAA)
PF01423 0.000394824 0.009176 7.98 1.04 6 19 LSM domain
PF00012 0.000652478 0.013901 9.60 0.76 5 14 Hsp70 protein
PF00619 0.00079263 0.016431 5.50 1.59 7 29 Caspase recruitment domain
PF00240 0.000900098 0.016650 4.61 2.08 8 38 Ubiquitin family
PF00179 0.001078646 0.019240 4.47 2.14 8 39 Ubiquitin-conjugating enzyme
PF02809 0.001298505 0.022635 7.85 0.87 5 16 Ubiquitin interaction motif
PF00615 0.002562437 0.033016 4.32 1.92 7 35 Regulator of G protein signaling domain
PF03144 0.002323914 0.033016 6.64 0.98 5 18 Elongation factor Tu domain 2
PF00009 0.003012875 0.033016 6.17 1.04 5 19 Elongation factor Tu GTP binding domain