PFAM IDs are linked to the PFAM website (http://pfam.sanger.ac.uk/). The list of HD-relevant genes for each category can be found following the links provided in the Term column.
| PFAMID | P-Value | FDR | Odds Ratio | Expected Count | Count | Total number | Term |
|---|---|---|---|---|---|---|---|
| PF00069 | 1.76E-09 | 1.19E-06 | 3.20 | 14.44 | 41 | 362 | Protein kinase domain |
| PF00011 | 2.99E-07 | 7.07E-05 | 48.55 | 0.35 | 6 | 9 | Hsp20/alpha crystallin family |
| PF00227 | 3.15E-07 | 7.07E-05 | 17.70 | 0.75 | 8 | 19 | Proteasome A-type and B-type |
| PF00850 | 1.53E-06 | 0.000258 | 29.12 | 0.43 | 6 | 11 | Histone deacetylase domain |
| PF00454 | 5.16E-06 | 0.000695 | 14 | 0.75 | 7 | 19 | Phosphatidylinositol 3- and 4-kinase |
| PF00226 | 1.30E-05 | 0.000970 | 6.58 | 1.87 | 10 | 47 | DnaJ domain |
| PF00004 | 1.58E-05 | 0.001064 | 6.41 | 1.91 | 10 | 48 | ATPase family associated with various cellular activities (AAA) |
| PF00118 | 2.24E-05 | 0.001370 | 14.56 | 0.63 | 6 | 16 | TCP-1/cpn60 chaperonin family |
| PF00060 | 4.85E-05 | 0.002511 | 12.13 | 0.71 | 6 | 18 | Ligand-gated ion channel |
| PF10613 | 4.85E-05 | 0.002511 | 12.13 | 0.71 | 6 | 18 | Ligated ion channel L-glutamate- and glycine-binding site |
| PF01423 | 6.85E-05 | 0.003073 | 11.19 | 0.75 | 6 | 19 | LSM domain |
| PF01094 | 8.51E-05 | 0.003579 | 6.70 | 1.47 | 8 | 37 | Receptor family ligand binding region |
| PF00240 | 0.000104 | 0.004119 | 6.48 | 1.51 | 8 | 38 | Ubiquitin family |
| PF00179 | 0.000126 | 0.004522 | 6.27 | 1.55 | 8 | 39 | Ubiquitin-conjugating enzyme |
| PF00233 | 0.000127 | 0.004522 | 9.70 | 0.83 | 6 | 21 | 3'5'-cyclic nucleotide phosphodiesterase |
| PF00012 | 0.000147 | 0.004522 | 13.46 | 0.55 | 5 | 14 | Hsp70 protein |
| PF00656 | 0.000147 | 0.004522 | 13.46 | 0.55 | 5 | 14 | Caspase domain |
| PF00433 | 0.000152 | 0.004522 | 6.07 | 1.59 | 8 | 40 | Protein kinase C terminal domain |
| PF03144 | 0.000553 | 0.013787 | 9.31 | 0.71 | 5 | 18 | Elongation factor Tu domain 2 |
| PF00009 | 0.000726 | 0.017455 | 8.65 | 0.75 | 5 | 19 | Elongation factor Tu GTP binding domain |
| PF00619 | 0.005335 | 0.065282 | 5.04 | 1.15 | 5 | 29 | Caspase recruitment domain |
| PF00071 | 0.005819 | 0.068949 | 2.47 | 5.18 | 12 | 130 | Ras family |
| PF00400 | 0.009287 | 0.091922 | 2.08 | 7.57 | 15 | 190 | WD domain, G-beta repeat |
| PF02985 | 0.020058 | 0.124299 | 3.02 | 2.15 | 6 | 54 | HEAT repeat |
| PF00018 | 0.030319 | 0.124299 | 1.92 | 6.50 | 12 | 163 | SH3 domain |
| PF00105 | 0.035482 | 0.124299 | 2.94 | 1.83 | 5 | 46 | Zinc finger, C4 type (two domains) |
| PF00104 | 0.041572 | 0.128932 | 2.81 | 1.91 | 5 | 48 | Ligand-binding domain of nuclear hormone receptor |
| PF00271 | 0.064168 | 0.162933 | 1.95 | 4.26 | 8 | 107 | Helicase conserved C-terminal domain |