Kamesh´s picture

Kameshwar R Ayasolla, PhD

Postdoctoral Research Fellow (Alumnus)
Faculty of Sciences and Technology (building 8)
University of Algarve
Phone: + 351 289 244 403 (extn. 7136)

1982 - 1985: BS, Osmania University, Hyderabad, India
1985 - 1988: MS, University of Hyderabad, India
1988 - 1995: PhD, Neurochemistry, Christian Medical College Hospital, Vellore, India

Post-doctoral training
1995 - 1996: Cancer Biology Division, Madurai Kamaraj University, Madurai, India.
1996 - 1998: Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
1998 - 2005: Department of Pediatrics, MUSC Hospital, Charleston, South Carolina, USA.

2005 - 2007: Research Specialist, Dept of Pediatrics/OB/GY, MUSC Hospital, Charleston, USA
2008 - 2010: Dept of Chemistry, Bar-Ilan University, Ramat Gan, Israel
2010 - 2011: Postdoctoral fellow in Systems Biology and Bioinformatics, CBME, University of Algarve, Faro, Portugal

Advisory activities
• Reviewer for Biomedical Research Council of Singapore Grant Proposals
• Registered reviewer for FP7 (European Commission)
• Reviewer, of International Alzheimer’s Association Grant Award
• Reviewer for Journal of Neural Transmission
• Reviewer for Apoptosis

Fellowships and Honors
1988-91: Junior Research Fellowship, Council of Scientific & Industrial Research, India
1991-95: Senior Research Fellowship, Council of Scientific & Industrial Research, India
1995-96: Post-doctoral Fellowship, Council of Scientific & Industrial Research, India
1997 : International Society for Neurochemistry Travel Award
2006 : Investigator Award XV World Congress of the International Society for the study of Hypertension in Pregnancy, Lisbon , Portugal
2010 : ISTAART Travel Award ICAD 2010

• International Society for Neurochemistry
• ISTAART (International Alzheimer´s Association)
• Global Medical Research.org
• Member Health Care, Bio, Pharma and Life Sciences
• Member Stem Cell Research
• Member Systems Biology for Medical Research

Ayasolla KR, Cherian R, Balasubramanian AS.
Sulfation of proteins in the primate cerebellum and young rat brain. Neurochem Int. 1993; 22(5):465-70. PMID:8485452

Ayasolla KR, Balasubramanian AS.
Phosphorylation of casein, fibrinogen and calmodulin by a glycoprotein protein kinase from monkey cerebellum: a casein kinase II-like enzyme. Indian J Biochem Biophys. 1994; 31(5):392-7. PMID:7851939

Ayasolla K.R., Richter-Landsberg C., Seger R., Givol D., and Yavin E.J.
H2O2-Induced apoptotic death in serum-deprived cultures of oligodendroglia origin is linked to cell differentiation. Journal of Neuroscience Research 1999; 56: 447-556 PMID:10369212 (PDF)

Uberti D, Yavin E, Gil S, Ayasolla KR, Goldfinger N, and Rotter V.
Hydrogen peroxide induces nuclear translocation of p53 and apoptosis in cells of oligodendroglia origin. Mol. Brain Res. 1999; 65: 167-175. PMID:10064887 (PDF)

Ayasolla K, Singh AK, and Singh I.
Vitamin E restores Amyloid peptide (25-35) induced changes in Cellular redox in C6 glioma cells. Society for Free Radical Biology Special Edition. Monduzzi Editore S.P.A. - Medimond Inc. 2003.

Ayasolla KR, Khan M, Singh AK, and Singh I.
Inflammatory mediators and beta amyloid (25-35) induced ceramide generation and iNOS expression is inhibited by vitamin E. Free Rad Biol. Med. 2004; 37(3): 325-38. PMID:15223066 (PDF)

Khan M, Sekhon B, Giri S, Jatana M, Gilg AG, Ayasolla K.R, Elango C, Singh AK, and Singh I.
S-Nitrosoglutathione reduces inflammation and protects brain against focal cerebral ischemia in a rat model of experimental stroke. J Cereb Blood Flow Metab. 2005; 25(2):177-92. (PDF) PMID:15647746

Ayasolla K, Singh AK, and Singh I.
5-aminoimidazole-4-carboxyamide-14-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Aß peptide–induced inflammatory mediators in astroglia. J of Neuroinflammation 2005, 2:21. PMID:16174294 (PDF)

Ayasolla KR, Avtar K Singh and Inderjit Singh.
Differential effects of Aluminum and Lithium on LPS and A ß-(25–35) induced iNOS gene expression in glia and in TAU hyperphosphorylation and on neurite inhibition. The FASEB Journal. 2007;21:823.

Ayasolla KR, E . Chang , R . Newman , J . Van Dorsten , I. Singh.
N-acetylcysteine (NAC) reverses the alterations in antioxidant enzymes seen in the reduced uterine perfusion pressure model (RUPP) of preeclampsia . American Journal of Obstetrics and Gynecology , Volume 195 , Issue 6 Pages S145 - S145 K .

Laura Goetzl, Ayasolla K.R, and Inderjit Singh.
Multiple intrapartum insults at term: A model of neurodevelopmental injury. American Journal of Obstetrics and Gynecology 2006 Dec;195(6)S187

Ayasolla KR, Eugene Chang, Roger Newman, J. Peter Van Dorsten and Inderjit Singh.
N-Acetylcysteine (NAC) reverses alterations in angiogenic factors in the reduced uterine perfusion pressure model (RUPP) of preeclampsia.The FASEB Journal. 2007;21:865.9

Ravi Kiran Reddy Kalathur, Joaquin Giner-Lamia, Susana Machado, Kameshwar R S Ayasolla, and Matthias E. Futschik (2015) The unfolded protein response and its potential role in Huntington's disease elucidated by a systems biology approach, F1000Research 4:103 (pdf + html)