Molecular Functions enriched in HD-relevant genes

GO IDs are linked to the Gene Ontology website (www.geneontology.org). The list of HD-relevant genes for each category can be found following the links provided in the Term column.

GOMFID P-Value FDR Odds Ratio Expected Count Count Total number Term
GO:0005515 5.29E-48 4.88E-45 3.51 330.67 509 7636 protein binding
GO:0000166 7.08E-17 3.27E-14 2.23 95.18 175 2198 nucleotide binding
GO:0032553 3.24E-16 7.49E-14 2.31 78.29 151 1808 ribonucleotide binding
GO:0032555 3.24E-16 7.49E-14 2.31 78.29 151 1808 purine ribonucleotide binding
GO:0017076 5.14E-16 9.49E-14 2.27 81.71 155 1887 purine nucleotide binding
GO:0005488 1.46E-14 2.25E-12 2.55 531.82 602 12281 binding
GO:0032559 6.21E-13 7.20E-11 2.23 63.48 122 1466 adenyl ribonucleotide binding
GO:0005524 6.24E-13 7.20E-11 2.23 62.74 121 1449 ATP binding
GO:0030554 9.13E-13 9.37E-11 2.19 66.81 126 1543 adenyl nucleotide binding
GO:0001882 1.36E-12 1.25E-10 2.17 67.94 127 1569 nucleoside binding
GO:0001883 1.89E-12 1.59E-10 2.16 67.51 126 1559 purine nucleoside binding
GO:0003735 6.31E-12 4.86E-10 5.37 6.84 30 158 structural constituent of ribosome
GO:0017111 1.54E-10 1.09E-08 2.57 29.88 68 690 nucleoside-triphosphatase activity
GO:0003824 6.85E-10 4.52E-08 1.64 219.25 293 5063 catalytic activity
GO:0016462 8.98E-10 5.53E-08 2.45 31.13 68 719 pyrophosphatase activity
GO:0016818 1.07E-09 5.90E-08 2.44 31.26 68 722 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0008134 1.08E-09 5.90E-08 2.85 20.22 51 467 transcription factor binding
GO:0016817 1.35E-09 6.92E-08 2.43 31.43 68 726 hydrolase activity, acting on acid anhydrides
GO:0042802 3.70E-09 1.80E-07 2.62 23.51 55 543 identical protein binding
GO:0004674 4.25E-09 1.96E-07 2.89 17.92 46 414 protein serine/threonine kinase activity
GO:0016787 5.73E-08 2.30E-06 1.71 95.87 146 2214 hydrolase activity
GO:0003924 2.17E-07 7.82E-06 3.58 8.27 26 191 GTPase activity
GO:0005198 2.20E-07 7.82E-06 2.30 25.80 54 596 structural molecule activity
GO:0003723 3.80E-07 1.25E-05 2.16 30.48 60 704 RNA binding
GO:0016773 7.44E-07 2.37E-05 2.14 29.66 58 685 phosphotransferase activity, alcohol group as acceptor
GO:0019899 1.02E-06 2.85E-05 2.51 17.53 40 405 enzyme binding
GO:0016887 1.05E-06 2.85E-05 2.74 13.72 34 317 ATPase activity
GO:0004672 1.80E-06 4.75E-05 2.20 24.77 50 572 protein kinase activity
GO:0019904 1.87E-06 4.79E-05 2.93 10.99 29 254 protein domain specific binding
GO:0016301 4.65E-06 0.000110 1.99 32.17 59 743 kinase activity
GO:0042623 1.37E-05 0.000294 2.72 10.91 27 252 ATPase activity, coupled
GO:0046983 2.02E-05 0.000415 2.20 19.14 39 442 protein dimerization activity
GO:0042803 2.30E-05 0.000461 2.58 11.86 28 274 protein homodimerization activity
GO:0016772 5.73E-05 0.001058 1.77 38.15 63 881 transferase activity, transferring phosphorus-containing groups
GO:0004175 6.71E-05 0.001215 2.23 15.97 33 369 endopeptidase activity
GO:0003712 0.000131 0.002134 2.23 14.46 30 334 transcription cofactor activity
GO:0016563 0.000489 0.006848 2.08 14.89 29 344 transcription activator activity
GO:0005525 0.000599 0.008146 2.02 15.80 30 365 GTP binding
GO:0019001 0.000889 0.010813 1.97 16.19 30 374 guanyl nucleotide binding
GO:0032561 0.000889 0.010813 1.97 16.19 30 374 guanyl ribonucleotide binding
GO:0008233 0.001287 0.014361 1.74 24.20 40 559 peptidase activity
GO:0005215 0.002216 0.019691 1.48 49.75 70 1149 transporter activity
GO:0070011 0.002258 0.019872 1.71 23.38 38 540 peptidase activity, acting on L-amino acid peptides
GO:0022892 0.002310 0.020143 1.53 40.53 59 936 substrate-specific transporter activity
GO:0022891 0.003508 0.026569 1.54 34.60 51 799 substrate-specific transmembrane transporter activity
GO:0016874 0.003660 0.027500 1.81 16.23 28 375 ligase activity
GO:0015075 0.008814 0.055784 1.51 30.39 44 702 ion transmembrane transporter activity
GO:0022857 0.013846 0.076613 1.42 38.10 52 880 transmembrane transporter activity
GO:0008324 0.014872 0.081313 1.53 22.99 34 531 cation transmembrane transporter activity
GO:0008092 0.043122 0.142897 1.45 19.87 28 459 cytoskeletal protein binding
GO:0000287 0.047878 0.152307 1.44 19.22 27 444 magnesium ion binding
GO:0030528 0.051371 0.160906 1.24 62.31 75 1439 transcription regulator activity
GO:0016740 0.056652 0.171627 1.21 71.92 85 1661 transferase activity
GO:0030234 0.070997 0.206043 1.28 35.07 44 810 enzyme regulator activity