Molecular Functions enriched in HD-relevant genes

GO IDs are linked to the Gene Ontology website (www.geneontology.org). The list of HD-relevant genes for each category can be found following the links provided in the Term column.

GOMFID P-Value FDR Odds Ratio Expected Count Count Total number Term
GO:0005515 4.44E-42 5.10E-39 2.64 456.23 652 7636 protein binding
GO:0000166 6.65E-23 3.81E-20 2.27 131.32 241 2198 nucleotide binding
GO:0032553 1.19E-21 3.41E-19 2.33 108.02 207 1808 ribonucleotide binding
GO:0032555 1.19E-21 3.41E-19 2.33 108.02 207 1808 purine ribonucleotide binding
GO:0017076 1.49E-21 3.43E-19 2.30 112.74 213 1887 purine nucleotide binding
GO:0032559 1.20E-19 2.29E-17 2.38 87.59 174 1466 adenyl ribonucleotide binding
GO:0001882 1.69E-19 2.42E-17 2.33 93.74 182 1569 nucleoside binding
GO:0030554 1.54E-19 2.42E-17 2.34 92.19 180 1543 adenyl nucleotide binding
GO:0001883 1.99E-19 2.53E-17 2.33 93.14 181 1559 purine nucleoside binding
GO:0005524 6.31E-18 6.58E-16 2.30 86.57 168 1449 ATP binding
GO:0004674 1.53E-15 1.19E-13 3.38 24.73 70 414 protein serine/threonine kinase activity
GO:0003824 1.54E-14 1.04E-12 1.70 302.50 410 5063 catalytic activity
GO:0016773 4.61E-14 2.93E-12 2.63 40.92 93 685 phosphotransferase activity, alcohol group as acceptor
GO:0004672 8.36E-14 5.05E-12 2.79 34.17 82 572 protein kinase activity
GO:0042802 1.11E-13 6.35E-12 2.83 32.44 79 543 identical protein binding
GO:0016301 9.22E-13 4.81E-11 2.45 44.39 95 743 kinase activity
GO:0043176 9.68E-12 4.63E-10 6.82 5.01 25 84 amine binding
GO:0005488 6.02E-11 2.66E-09 1.88 733.77 805 12281 binding
GO:0042803 1.59E-10 6.74E-09 3.29 16.37 46 274 protein homodimerization activity
GO:0016772 5.46E-10 2.09E-08 2.11 52.63 99 881 transferase activity, transferring phosphorus-containing groups
GO:0046983 6.92E-10 2.53E-08 2.62 26.40 61 442 protein dimerization activity
GO:0008134 9.17E-10 3.19E-08 2.56 27.90 63 467 transcription factor binding
GO:0019899 1.22E-09 3.99E-08 2.68 24.19 57 405 enzyme binding
GO:0015276 2.35E-09 7.08E-08 4.57 7.28 27 122 ligand-gated ion channel activity
GO:0022834 2.35E-09 7.08E-08 4.57 7.28 27 122 ligand-gated channel activity
GO:0016787 1.34E-08 3.84E-07 1.63 132.28 193 2214 hydrolase activity
GO:0003735 1.40E-08 3.84E-07 3.77 9.44 30 158 structural constituent of ribosome
GO:0005057 1.40E-08 3.84E-07 3.77 9.44 30 158 receptor signaling protein activity
GO:0022891 2.93E-08 7.47E-07 2.02 47.73 87 799 substrate-specific transmembrane transporter activity
GO:0004871 1.05E-07 2.26E-06 1.60 126.42 182 2116 signal transducer activity
GO:0060089 1.05E-07 2.26E-06 1.60 126.42 182 2116 molecular transducer activity
GO:0022892 1.01E-07 2.26E-06 1.89 55.92 96 936 substrate-specific transporter activity
GO:0008324 1.30E-07 2.77E-06 2.20 31.72 63 531 cation transmembrane transporter activity
GO:0015075 1.42E-07 2.97E-06 2.02 41.94 77 702 ion transmembrane transporter activity
GO:0017111 1.46E-07 2.98E-06 2.03 41.22 76 690 nucleoside-triphosphatase activity
GO:0019904 1.49E-07 2.99E-06 2.84 15.17 38 254 protein domain specific binding
GO:0016462 3.76E-07 7.19E-06 1.96 42.95 77 719 pyrophosphatase activity
GO:0016818 4.44E-07 8.35E-06 1.95 43.13 77 722 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016817 5.53E-07 1.01E-05 1.94 43.37 77 726 hydrolase activity, acting on acid anhydrides
GO:0005215 6.98E-07 1.25E-05 1.73 68.65 109 1149 transporter activity
GO:0022857 1.07E-06 1.77E-05 1.82 52.57 88 880 transmembrane transporter activity
GO:0003924 2.64E-05 0.000352 2.63 11.41 27 191 GTPase activity
GO:0022836 2.77E-05 0.000365 2.23 18.10 37 303 gated channel activity
GO:0005216 6.03E-05 0.000728 2.03 22.34 42 374 ion channel activity
GO:0016887 7.33E-05 0.000866 2.12 18.94 37 317 ATPase activity
GO:0022838 0.000109535 0.001185 1.97 22.94 42 384 substrate specific channel activity
GO:0016740 0.000151003 0.001574 1.44 99.24 134 1661 transferase activity
GO:0048037 0.000184207 0.001886 2.27 13.44 28 225 cofactor binding
GO:0015267 0.000203718 0.001902 1.91 23.60 42 395 channel activity
GO:0022803 0.000203718 0.001902 1.91 23.60 42 395 passive transmembrane transporter activity
GO:0003712 0.00021402 0.001902 2.00 19.95 37 334 transcription cofactor activity
GO:0008289 0.000286859 0.002473 1.79 28.55 48 478 lipid binding
GO:0005261 0.000415601 0.003505 2.08 15.53 30 260 cation channel activity
GO:0005198 0.000502859 0.004090 1.67 35.61 56 596 structural molecule activity
GO:0004888 0.000731283 0.005667 1.44 74.86 102 1253 transmembrane receptor activity
GO:0004175 0.000744455 0.005730 1.84 22.04 38 369 endopeptidase activity
GO:0003723 0.000825161 0.006028 1.58 42.06 63 704 RNA binding
GO:0042623 0.001148019 0.007980 1.99 15.05 28 252 ATPase activity, coupled
GO:0022804 0.00161054 0.010740 1.80 20.67 35 346 active transmembrane transporter activity
GO:0046873 0.002007893 0.012382 1.82 18.64 32 312 metal ion transmembrane transporter activity
GO:0016564 0.002174276 0.013336 1.90 15.71 28 263 transcription repressor activity
GO:0016563 0.002723466 0.016269 1.75 20.55 34 344 transcription activator activity
GO:0019001 0.003234487 0.018019 1.70 22.34 36 374 guanyl nucleotide binding
GO:0032561 0.003234487 0.018019 1.70 22.34 36 374 guanyl ribonucleotide binding
GO:0000287 0.003701478 0.018260 1.62 26.52 41 444 magnesium ion binding
GO:0005525 0.006820588 0.032327 1.64 21.80 34 365 GTP binding
GO:0004872 0.007296538 0.034440 1.29 100.55 124 1683 receptor activity